Effects of parabiosis of normal with genetically diabetic mice.
Effects of parabiosis of normal with genetically diabetic mice.
复制标题
正常小鼠与遗传性糖尿病小鼠联体共生的影响。
DOI：
10.1152/ajplegacy.1969.217.5.1298
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
Katharine P Hummel Effects
中科院分区：
文献类型：
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作者：
D. Coleman;K. Hummel;Katharine P Hummel Effects
科尔曼博士和凯瑟琳p.哈默尔。正常小鼠与遗传性糖尿病小鼠异种共生的影响。点。[j] .生物医学工程学报，2017,31(5):1299 - 1294。1969.-将C57BL/Ks菌株的成年糖尿病小鼠（db/db）与同性正常小鼠异种共生。在糖尿病患者中观察到的疾病改善很少，如果有的话，在正常的糖尿病患者中没有观察到糖尿病的症状。相反，正常的伴侣体重下降，出现低血糖，并在手术后50天内死于明显的饥饿。相比之下，糖尿病伴侣体重迅速增加并保持糖尿病状态。讨论了这种反应与正常大鼠与下丘脑腹内侧核区有病变的大鼠异种共生时的相似之处。
COLEMAN, D. L., AND KATHARINE P. HUMMEL. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 2 17(5) : 129% 1304. 1969.-Adult diabetic mice (db/db) of the C57BL/Ks strain were joined in parabiosis with normal mice of the same sex. Little, if any, amelioration of the disease was observed in parabiont diabetics and no symptoms of diabetes were observed in the normal parabiont. Instead, the normal partners lost weight, became hypoglycemic, and died of apparent starvation within 50 days after surgery. In contrast, the diabetic partners gained weight rapidly and remained diabetic. The similarity of this response to that observed with normal rats in parabiosis with rats having lesions in the region of the ventromedial nuclei of the hypothalamus is discussed.