Dark-Adapted Chromatic Perimetry for Measuring Rod Visual Fields in Patients with Retinitis Pigmentosa
Dark-Adapted Chromatic Perimetry for Measuring Rod Visual Fields in Patients with Retinitis Pigmentosa
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DOI：
10.1167/tvst.6.4.15
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发表时间：
2017-07-01
影响因子：
3
通讯作者：
Birch, David G.
中科院分区：
文献类型：
--
作者：
Bennett, Lea D.;Klein, Martin;Birch, David G.
目的：尽管视杆细胞感光器最初在视网膜色素变性（RP）中受到影响，但由于检测视杆细胞敏感性的商业设备不可用，因此视杆细胞视觉的全视野没有常规表征。本研究的目的是量化杆介导的视力在周边领域的RP患者使用一个新的市售perimeter.Methods：参与者有一只眼睛扩张和黑暗适应45分钟。暗适应色（DAC）周边测试80个位点1448水平和728垂直与青色刺激。视杆细胞介导的基因座（RML）的数量进行了分析的基础上，正常的视锥细胞敏感性（方法1）和相关的全视野视网膜电图（ERG）反应的Pearson的r相关和线性回归。在第二组RP患者中，通过双色视野检查（青色和红色;方法2）确定RML。结果：方法1 RML与0.01cd的反应相关。s/m2闪光（P < 0.001），而对青色刺激的总敏感度与对3.0 cd的反应相关。s/m（2）闪光（P < 0.0001）。方法2比方法1平均多检测10个RML。结论：使用DAC测量的暗视野可检测到整个视野的视杆敏感性，即使在一些无法检测到视杆ERG的患者中也是如此。当对青色刺激的敏感性降低到
Purpose: Although rod photoreceptors are initially affected in retinitis pigmentosa (RP), the full-field of rod vision is not routinely characterized due to the unavailability of commercial devices detecting rod sensitivity. The purpose of this study was to quantify rod-mediated vision in the peripheral field from patients with RP using a new commercially available perimeter.Methods: Participants had one eye dilated and dark-adapted for 45 minutes. A darkadapted chromatic (DAC) perimeter tested 80 loci 1448 horizontally and 728 vertically with cyan stimuli. The number of rod-mediated loci (RML) were analyzed based on normal cone sensitivity (method 1) and associated with full-field electroretinography (ERG) responses by Pearson's r correlation and linear regression. In a second cohort of patients with RP, RML were identified by two-color perimetry (cyan and red; method 2). The two methods for ascribing rod function were compared by Bland-Altman analysis.Results: Method 1 RML were correlated with responses to the 0.01 cd. s/m(2) flash (P < 0.001), while total sensitivity to the cyan stimulus showed correlation with responses to the 3.0 cd. s/m(2) flash (P < 0.0001). Method 2 detected a mean of 10 additional RML compared to method 1.Conclusions: Scotopic fields measured with the DAC detected rod sensitivity across the full visual field, even in some patients who had nondetectable rod ERGs. Twocolor perimetry is warranted when sensitivity to the cyan stimulus is reduced to