Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study
Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study
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DOI：
10.1177/0960327115573597
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发表时间：
2016-01-01
影响因子：
2.8
通讯作者：
Al Amri, M. Ali
中科院分区：
文献类型：
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作者：
Al-Asmari, A. K.;Al-Zahrani, A. M.;Al Amri, M. Ali
5-氟尿嘧啶是治疗各种类型癌症的最常用的抗癌药物之一，但具有潜在的不良反应，如肠粘膜炎、肾、肝和生殖器官毒性。减少化疗药物的副作用和提高化疗药物疗效的方法已引起人们的关注。本研究观察了牛磺酸（Tau）对5-氟尿嘧啶（5-FU）所致大鼠肝损伤的保护作用。将动物分为四组，每组6只动物（n = 6）。组I仅接受媒介物并作为对照组。第II、III和IV组动物经口灌胃给予50 mg/kg体重的5-FU，持续4天。在5-FU给药前30分钟，将Tau给予组III和组IV的动物。我们观察到5-FU给药后髓过氧化物酶（MPO）活性显著升高，Tau预处理可逆转。肝、肾、肠、睾丸和前列腺的组织学观察显示，5-FU给药导致异常，如正常细胞结构的扭曲、炎性细胞的浸润和细胞完整性的丧失。这些组织病理学变化被Tau治疗显著抑制。总之，本研究的生化和组织学结果表明，Tau对抗癌药物5-FU的并发症具有很强的预防潜力，因此Tau可能在联合化疗中发挥重要作用，以提高抗癌药物的治疗效果。
5-Fluorouracil is one of the most commonly used anticancer drugs for the treatment of various types of cancer but has potential adverse effects such as intestinal mucositis, renal, hepatic, and reproductive organ toxicity. Attention has been given to approaches to reduce the side effects and improve the therapeutic effectiveness of chemotherapeutic drugs. In this study, we have investigated the protective effect of taurine (Tau) on 5-fluorouracil (5-FU) induced adverse effects in Wistar rats. Animals were divided into four groups with six animals (n = 6) in each group. Group I received vehicle only and served as control group. Groups II, III, and IV animals were given oral gavage of 5-FU at 50 mg/kg body weight for 4 days. Tau was given to the animals of groups III and IV 30 min prior to 5-FU administration. We observed marked elevation in the myeloperoxidase (MPO) activity after 5-FU administration, which was reversed by Tau pretreatment. Histological observation of liver, kidney, intestine, testis, and prostate revealed that 5-FU administration resulted in anomalies like distortion of normal cellular architecture, infiltration of inflammatory cells, and loss of cellular integrity. These histopathological changes were markedly suppressed by Tau treatment. In conclusion, biochemical and histological findings of this study suggest that Tau has strong preventive potential against complications of anticancer drug 5-FU and hence Tau may play an important role in combinational chemotherapy to enhance the therapeutic efficacy of anticancer drugs.