On the biodegradation of poly-β-hydroxybutyrate (PHB) homopolymer and poly-β-hydroxybutyrate-hydroxyvalerate copolymers
On the biodegradation of poly-β-hydroxybutyrate (PHB) homopolymer and poly-β-hydroxybutyrate-hydroxyvalerate copolymers
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DOI：
10.1016/0142-9612(87)90102-5
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发表时间：
1987-03
期刊：
影响因子：
14
通讯作者：
N. D. Miller;David F. Williams
中科院分区：
文献类型：
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作者：
N. D. Miller;David F. Williams
已知的生物降解性的聚羟基丁酸酯在某些生物环境中已导致其建议使用作为一个'生物可降解的'植入材料。本文研究了聚羟基苯甲酸酯（PHB）均聚物和两种PHV-PHB共聚物的单丝在体内和体外的力学性能和形貌的变化，在体内只有在植入前经10.0Mrad γ射线预降解的PHB才观察到生物降解。高温水解实验表明，PHV共聚物的加入延缓了PHB的降解速率。水化反应对材料的极限拉伸性能影响最大。相比之下，弹性性能似乎相对不受影响。
The known biodegradability of PHB in certain biological environments has led to its proposed use as a ‘biodegradable’ implant material. Monofilaments of PHB homopolymer and two PHV-PHB copolymers have been studiedin vivoandin vitroand assessed for changes in mechanical properties and topography.In vivobiodegradation was only observed with PHB when pre-degraded by 10.0 Mrad of γ-irradiation before implantation. High temperaturein vitrohydrolysis suggested that PHV copolymer additions retarded the rate of degradation of PHB. Hydration reactions had most effect on the ultimate tensile properties of the materials. In contrast, the elastic properties appeared to be relatively unaffected.