Graft-versus-host disease: a disorder of tissue regeneration and repair
Graft-versus-host disease: a disorder of tissue regeneration and repair
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DOI：
10.1182/blood.2021011867
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发表时间：
2021-11-04
期刊：
影响因子：
20.3
通讯作者：
Teshima, Takanori
中科院分区：
文献类型：
--
作者：
Chakraverty, Ronjon;Teshima, Takanori
屏障表面的再生失败和导致纤维化的适应不良修复是移植物抗宿主病（GVHD）的标志。虽然免疫抑制治疗可以控制炎症，但受损的组织稳态会导致器官损伤延长和生活质量受损。在这篇血液聚焦中，我们回顾了最近的研究，这些研究解决了组织再生和修复的关键失败，这些失败是治疗抵抗性GVHD的基础。我们强调目前的干预措施，旨在克服这些缺陷，并提供我们对未来的治疗前景的评估。
Regenerative failure at barrier surfaces and maladaptive repair leading to fibrosis are hallmarks of graft-versus-host disease (GVHD). Although immunosuppressive treatment can control inflammation, impaired tissue homeostasis leads to prolonged organ damage and impaired quality of life. In this Blood Spotlight, we review recent research that addresses the critical failures in tissue regeneration and repair that underpin treatment-resistant GVHD. We highlight current interventions designed to overcome these defects and provide our assessment of the future therapeutic landscape.