THE HISTOLOGICAL LESIONS OF EXPERIMENTAL GLANDERS.
THE HISTOLOGICAL LESIONS OF EXPERIMENTAL GLANDERS.
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DOI：
10.1084/jem.9.4.352
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发表时间：
1907-07-17
期刊：
影响因子：
--
通讯作者：
White PG
中科院分区：
文献类型：
--
作者：
Duval CW;White PG
鼻疽杆菌的毒力可能会发生改变，从而在实验上产生组织学特征差异很大的病变。高毒力培养物导致组织原发性坏死和解体，随后多形核白细胞侵入损伤区域。中等毒力的杆菌引起急性炎症性质的原发性病变，其中细胞没有表现出坏死或崩解的证据。减毒杆菌产生初级组织增殖，并形成上皮样细胞和巨细胞。根据培养物的毒性，急性渗出性和慢性增殖性之间存在各种级别的损伤。鼻疽病灶无论是渗出性还是增殖性都是焦点特征。鼻疽杆菌的强毒素引起细胞变性或坏死并渗出，而稀弱的毒素则产生增殖。鼻疽巨细胞无疑起源于血液和淋巴管的内皮细胞，是内皮细胞的细胞核分裂形成的，而不是细胞融合形成的。在组织学上，由低毒力培养引起的鼻疽病灶是增殖性的，类似于结核病；病变是局灶性的，与鼻疽杆菌有密切关系。
The bacillus of glanders may be so modified in virulence as to produce experimentally lesions differing widely in their histological features. The highly virulent culture causes primary necrosis and disintegration of the tissue followed by the invasion of the injured area by polymorphonuclear leucocytes. The bacilli of moderate virulence give rise to a primary lesion of an acute inflammatory nature in which the cells show no evidence of necrosis or disintegration. The attenuated bacilli produce primary tissue proliferation with the formation of epithelioid and giant cells. There is every grade of lesion between the acute exudative and the chronic proliferative depending upon the toxicity of the cultures. The glanders lesion whether exudative or proliferative is focal in character. The strong toxins of the glanders bacilli cause degeneration or necrosis of cells and exudation, while the dilute and weak toxins produce proliferation. The giant cell of glanders undoubtedly originates from the endothelial cell of the blood and lymph channels and is formed by division of the nucleus of the endothelial cell and not by cell fusion. Histologically the lesion of glanders resulting from the culture of a low degree of virulence is proliferative and is analogous to tuberculosis; the lesions are focal and bear an intimate relation to the glanders bacillus.