Non-Viral Delivery To Enable Genome Editing.
Non-Viral Delivery To Enable Genome Editing.
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DOI：
10.1016/j.tibtech.2018.08.010
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发表时间：
2019-03
影响因子：
17.3
通讯作者：
Green JJ
中科院分区：
文献类型：
--
作者：
Rui Y;Wilson DR;Green JJ
Genome editing technologies such as zinc finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeat/CRISPR-associated protein system have revolutionized biological research. Each biotechnology consists of a DNA binding protein that can be programmed to recognize and initiate double stranded breaks for sitespecific gene modification. These technologies have the potential to be harnessed to cure diseases caused by aberrant gene expression. In order to be successful therapeutically, their functionality depends on their safe and efficient delivery into the cell nucleus. This review discusses the challenges in the delivery of genome editing tools and highlights recent innovations in non-viral delivery that have potential to overcome these limitations and advance the translation of genome editing towards patient care.
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影响因子：
64.8
作者：
Eyquem J;Mansilla-Soto J;Giavridis T;van der Stegen SJ;Hamieh M;Cunanan KM;Odak A;Gönen M;Sadelain M
通讯作者：
Sadelain M
影响因子：
15
作者：
Alsaiari, Shahad K.;Patil, Sachin;Khashab, Niveen M.
通讯作者：
Khashab, Niveen M.
通过反式编码的小 RNA 和宿主因子 RNase III 进行 CRISPR RNA 成熟。
影响因子：
64.8
作者：
Deltcheva, Elitza;Chylinski, Krzysztof;Sharma, Cynthia M.;Gonzales, Karine;Chao, Yanjie;Pirzada, Zaid A.;Eckert, Maria R.;Vogel, Joerg;Charpentier, Emmanuelle
通讯作者：
Charpentier, Emmanuelle
影响因子：
48
作者：
Gaj, Thomas;Guo, Jing;Kato, Yoshio;Sirk, Shannon J.;Barbas, Carlos F., III
通讯作者：
Barbas, Carlos F., III
影响因子：
17.1
作者：
Jackson MA;Werfel TA;Curvino EJ;Yu F;Kavanaugh TE;Sarett SM;Dockery MD;Kilchrist KV;Jackson AN;Giorgio TD;Duvall CL
通讯作者：
Duvall CL