HIGH-FREQUENCY STIMULATION OF THE BASOLATERAL AMYGDALA FACILITATES THE INDUCTION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS IN-VIVO
HIGH-FREQUENCY STIMULATION OF THE BASOLATERAL AMYGDALA FACILITATES THE INDUCTION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS IN-VIVO
复制标题
DOI：
10.1016/0168-0102(95)00894-7
复制
发表时间：
1995-05-01
影响因子：
2.9
通讯作者：
ABE, K
中科院分区：
文献类型：
--
作者：
IKEGAYA, Y;SAITO, H;ABE, K
我们研究了高频刺激基底外侧杏仁核（BLA）对麻醉大鼠内侧穿通通路（PP）-齿状回（DG）突触长时程增强（LTP）诱导的影响。同侧 BLA 的条件刺激（100 Hz 下 100 个脉冲）不会改变 DG 突触电位。然而，当 BLA 调理刺激与 PP 的弱强直刺激（20 Hz 下 20 个脉冲）同时应用时（单独使用不会诱发 LTP），则会诱发强 DG LTP。同时应用对侧BLA刺激和PP弱破伤风不诱导LTP。此外，同侧 BLA 刺激增强了 PP 中度强直刺激（60 Hz 下 30 个脉冲）诱导的 LTP 幅度，但没有进一步增强 PP 强强直刺激（100 Hz 下 100 个脉冲）诱导的 LTP 幅度。这些结果表明同侧 BLA 神经元在体内调节 DG LTP 的诱导。
We investigated the effect of high-frequency stimulation of the basolateral amygdala (BLA) on the induction of long-term potentiation (LTP) in the medial perforant path (PP)-dentate gyrus (DG) synapses of anesthetized rats. A conditioning stimulation (100 pulses at 100 Hz) of the ipsilateral BLA did not change the DG synaptic potential. However, when the BLA conditioning stimulation was applied at the same time as a weak tetanic stimulation of PP (20 pulses at 20 Hz) which alone did not induce LTP, robust DG LTP was induced. Simultaneous application of contralateral BLA stimulation and PP weak tetanus did not induce LTP. Moreover, the ipsilateral BLA stimulation enhanced the magnitude of LTP induced by a moderate tetanic stimulation of PP (30 pulses at 60 Hz), but did not further enhance the LTP induced by a strong tetanic stimulation of PP (100 pulses at 100 Hz). These results suggest that the ipsilateral BLA neurons modulate the induction of DG LTP in vivo.