Toxicity of iron and hydrogen peroxide: The Fenton reaction
Toxicity of iron and hydrogen peroxide: The Fenton reaction
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DOI：
10.1016/0378-4274(95)03532-x
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发表时间：
1995-12-01
影响因子：
3.5
通讯作者：
Winterbourn, CC
中科院分区：
文献类型：
--
作者：
Winterbourn, CC
铁和过氧化氢能够氧化多种底物并造成生物损伤。该反应被称为芬顿反应，很复杂，能够产生羟基自由基和更高氧化态的铁。讨论了其机制以及不同螯合剂对其的影响，以及对生物系统中获得的结果的解释。
Iron and hydrogen peroxide are capable of oxidizing a wide range of substrates and causing biological damage. The reaction, referred to as the Fenton reaction, is complex and capable of generating both hydroxyl radicals and higher oxidation states of the iron. The mechanism and how it is affected by different chelators, and the interpretation of results obtained in biological systems, are discussed.