INTERRELATION BETWEEN PLASMA TESTOSTERONE AND PLASMA-INSULIN IN HEALTHY ADULT MEN - THE TELECOM STUDY
INTERRELATION BETWEEN PLASMA TESTOSTERONE AND PLASMA-INSULIN IN HEALTHY ADULT MEN - THE TELECOM STUDY
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DOI：
10.1007/bf00402551
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发表时间：
1992-02-01
期刊：
影响因子：
8.2
通讯作者：
PAPOZ, L
中科院分区：
文献类型：
--
作者：
SIMON, D;PREZIOSI, P;PAPOZ, L
血浆胰岛素是男性糖尿病和心血管疾病的危险因素。我们调查了1292名健康成年男性职业样本中血浆睾酮和血浆胰岛素之间的关系。总血浆睾酮下降，每十年的年龄和胰岛素增加，每十年的年龄。在这些横断面数据中，睾酮和胰岛素之间的这种显著的分级负相关与年龄无关。这种关联有所降低，但无法通过在模型中添加肥胖和肩胛下皮褶来解释。调整饮酒、吸烟和血糖并没有实质性改变这种关联。这些结果与女性中雄激素与胰岛素的正相关性相反，并为高胰岛素血症对心血管疾病风险的影响提出了其他可能的解释。有必要进行前瞻性研究，以确定这种关联的方向和因果关系。
Plasma insulin is a risk factor for diabetes mellitus and cardiovascular disease in men. We investigated the association between plasma testosterone and plasma insulin in an occupational sample of 1292 healthy adult men. Total plasma testosterone decreased with each decade of age and insulin increased with each decade of age. In these cross-sectional data, this significant graded inverse association between testosterone and insulin was independent of age. The association was reduced but not explained by the addition of obesity and subscapular skinfold to the model. Adjustment for alcohol consumption, cigarette smoking and plasma glucose did not materially alter the association. These results are the reverse of the positive association of androgens with insulin in women and suggest alternative possible explanations for the effect of hyperinsulinaemia on cardiovascular disease risk. Prospective studies will be necessary to determine the direction and causal nature of this association.