A case of mixed ductal-endocrine carcinoma of the pancreas
A case of mixed ductal-endocrine carcinoma of the pancreas
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DOI：
10.1007/s00795-010-0533-0
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发表时间：
2011-03-01
影响因子：
1.8
通讯作者：
Nakasho, Keiji
中科院分区：
文献类型：
--
作者：
Hirano, Hiroshi;Terada, Nobuyuki;Nakasho, Keiji
一位66岁的男性病人，因诊断为下胆管癌，肿瘤位于下胆管周围，接受了保留胃的胰管切除术。肿瘤（3.5 x 2.5 cm）位于胰腺头部，并已侵入十二指肠的乏特氏乳头。组织学结果表明导管腺癌和内分泌肿瘤。导管腺癌成分表达癌胚抗原、细胞角蛋白（CK）-19、CK-20、碳水化合物19-9和淀粉酶，而占肿瘤约三分之一的内分泌成分表达胰高血糖素、神经元特异性烯醇化酶和嗜铬粒蛋白A。两种成分的Ki-67标记指数分别为49.7%和5.3%。在此，我们提出这一情况下，混合导管内分泌癌的胰腺。我们的研究结果表明，其侵略性的质量可能归因于腺癌成分具有高增殖潜力。
A 66-year-old male patient underwent a stomach-preserving pancreatoduodenectomy procedure because of a tumor located around the lower bile duct under the diagnosis of carcinoma of the lower bile duct. The tumor (3.5 x 2.5 cm) was found at the head of the pancreas and had invaded the papillae of Vater at the duodenum. Histology findings indicated both ductal adenocarcinoma and endocrine tumor. The ductal adenocarcinoma component expressed carcinoembryonic antigen, cytokeratin (CK)-19, CK-20, carbohydrate 19-9, and amylase, whereas the endocrine component, which occupied about one-third of the tumor, expressed glucagon, neuron-specific enolase, and chromogranin A. The Ki-67 labeling indices of the two components were 49.7% and 5.3%, respectively. Herein, we present this case of mixed ductal-endocrine carcinoma of the pancreas. Our findings indicate that its aggressive mass may be ascribable to the adenocarcinoma component with a high proliferative potential.