Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype-dependent manner
Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype-dependent manner
复制标题
丙型肝炎病毒 NS5A 的结构域 I 以基因型依赖性方式与 ACBD3 关联
DOI：
10.1111/1348-0421.12784
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Leiliang Zhang
中科院分区：
文献类型：
--
作者：
Yue Lu;Xiaojie Yang;Leiliang Zhang
Previously, it was found that the hepatitis C virus NS5A interacted with ACBD3 in a genotype‐dependent manner. However, the region in NS5A responsible for association with ACBD3 is not clear. Domain I of NS5A was identified as critical for ACBD3 binding. By comparing the differences of amino acids in domain I from different genotypes of NS5A, it was found that key amino acids potentially corresponded to the affinity of the NS5A‐ACBD3 interaction. The findings not only revealed that domain I of NS5A associates with ACBD3 but they also shed mechanistic light on how NS5A is associated with ACBD3 in a genotype‐dependent manner.
