Serum LH and FSH during sexual maturation in the male rat: effect of castration and cryptorchidism.
Serum LH and FSH during sexual maturation in the male rat: effect of castration and cryptorchidism.
复制标题
雄性大鼠性成熟过程中的血清 LH 和 FSH：去势和隐睾的影响。
DOI：
10.1210/endo-88-1-120
复制
发表时间：
1971
期刊：
影响因子：
4.8
通讯作者：
W. Odell
中科院分区：
文献类型：
--
作者：
R. Swerdloff;P. Walsh;H. Jacobs;W. Odell
Serum LH and FSH, testis weight (TW), ventral prostate weight (VPW) and testicular histology were assessed in the immature male rat from age 21 to 91 days. Intact, castrate and cryptorchid male rats were studied at biweekly intervals. In intact animals, TW and VPW increased with age; mature sperm were first observed at 49 days. At 21 days LH was 65% of adult levels and increased progressively with age. In contrast, FSH in immature rats was 2–3 times higher than adult levels. FSH was maximal at 35 days of age and fell with the appearance of mature sperm in the tubules. This fall in FSH and the development of spermatogenesis were prevented by cryptorchidism. FSH values in the cryptorchid rat continued to rise until 49 days, at which time VPW and LH were not different from the controls, indicating unaltered Leydig cell function. Two weeks following castration of 21-day-old rats, LH and FSH were 5 times higher than intact adult levels. Marked destruction of germinal epithelium by cryptorchidism failed to elev...
