[Successful treatment of an elderly patient with idiopathic thrombocytopenic purpura accompanied with chronic subdural hematoma, using a Chinese herbal medicine, EK-49, and ascorbic acid].
[Successful treatment of an elderly patient with idiopathic thrombocytopenic purpura accompanied with chronic subdural hematoma, using a Chinese herbal medicine, EK-49, and ascorbic acid].
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中药EK-49联合抗坏血酸成功治疗老年特发性血小板减少性紫癜伴慢性硬膜下血肿一例
DOI：
10.3143/geriatrics.38.224
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Hiroshi Ueoka
中科院分区：
文献类型：
--
作者：
Atsushi Hirano;Hiroshi Ueoka
一名88岁的妇女因头痛入院。头部CT扫描显示右侧硬膜下血肿。由于慢性血小板减少症，当地医生对她进行了随访。入院时外周血小板计数为0.5 × 10（4）/μ L，血清PAIgG水平较高。骨髓检查显示巨核细胞明显增多。诊断为特发性血小板减少性紫癜（ITP）伴慢性硬膜下血肿。给予泼尼松龙后，血小板计数一过性升高，硬膜下血肿改善。然而，血小板计数随着泼尼松龙剂量的减少而减少。然后开始联合给予中草药EK-49和抗坏血酸。血小板计数逐渐增加，未出现不良反应。这些结果表明，患有慢性硬膜下血肿的老年患者可以进行非侵入性治疗，并且EK-49和抗坏血酸联合治疗可能对治疗难治性ITP有效。
An 88 year-old woman was admitted complaining of headache. CT scan of the head revealed a right subdural hematoma. She had been followed by a local physician because of chronic thrombocytopenia. Her peripheral platelet count on admission was 0.5 x 10(4)/microliter, with a high serum level of PAIgG. Bone marrow examination revealed marked increase of megakaryocyte. Idiopathic thrombocytopenic purpura(ITP) accompanied with chronic subdural hematoma was diagnosed. Transient increase of platelet count and improvement of subdural hematoma was obtained by administration of prednisolone. However, platelet count decreased with tapering of prednisolone. Then combined administration of a Chinese herbal medicine, EK-49, and ascorbic acid was started. Platelet count gradually increased and no adverse effects were experienced. These results indicated that elderly patients with chronic subdural hematoma can be treated non-invasively, and that a combination of EK-49 and ascorbic acid may be effective in the treatment of refractory ITP.