Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults:: results from a large population-based study
Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults:: results from a large population-based study
复制标题
DOI：
10.1016/s0021-9150(99)00210-5
复制
发表时间：
1999-12-01
期刊：
影响因子：
5.3
通讯作者：
Koenig, W
中科院分区：
文献类型：
--
作者：
Brenner, H;Berg, G;Koenig, W
有人提出，幽门螺杆菌（H. pylori）慢性感染，特别是感染产生细胞毒素相关蛋白CagA的有毒菌株，可能通过产生持续的低度炎症刺激而增加冠心病的风险。我们在一个基于人群的1834名年龄在18 - 88岁的男性和女性样本中，评估了幽门螺杆菌感染的血清学标志物与各种全身性炎症标志物之间的关系。样本中共有39.3%的人出现免疫球蛋白G（IgG）阳性反应，其中略多于半数为CagA阳性。无论CagA状态如何，幽门螺杆菌感染与C反应蛋白和白细胞计数无关。幽门螺杆菌感染与血清白蛋白之间呈负相关。血清白蛋白水平处于最低三分之一与最高三分之一相比，感染CagA阳性和CagA阴性幽门螺杆菌菌株的调整后比值比（95%置信区间）分别为2.2（1.5 - 3.1）和2.0（1.4 - 3.1）。这些结果不支持幽门螺杆菌有毒菌株慢性感染会引发严重全身性炎症这一假说。幽门螺杆菌感染与血清白蛋白之间负相关的潜在机制以及这一发现的临床相关性需要进一步研究。（C）1999年爱尔兰爱思唯尔科学有限公司。版权所有。
It has been suggested that chronic infection with Helicobacter pylori (H. pylori), in particular infection with virulent strains producing the cytotoxin-associated protein CagA, may increase the risk of coronary heart disease by generation of a persistent low-grade inflammatory stimulus. We assessed the relation between serological markers of H. pylori infection and various markers of systemic inflammation in a population-based sample of 1834 men and women aged 18-88. A total of 39.3% of the sample had a positive IgG response, and among these a slight majority was CagA positive. Infection with H. pylori was unrelated to C-reactive protein and the leukocyte count, regardless of CagA status. There was an inverse relation between H. pylori infection and serum albumin. The adjusted OR (95% CI) of an albumin level in the bottom versus the top third were 2.2 (1.5-3.1) and 2.0 (1.4-3.1) for infection with CagA-positive and CagA-negative H. pylori strains, respectively. These results do not support the hypothesis that chronic infection with virulent H. pylori strains provokes major systemic inflammation. The mechanisms underlying the inverse association between H. pylori infection and serum albumin and the clinical relevance of this finding require further research. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.