Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis
Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis
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DOI：
10.1590/s1020-49892007000900001
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发表时间：
2007-10-01
期刊：
影响因子：
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通讯作者：
Vermund, Sten H.
中科院分区：
文献类型：
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作者：
Gotuzzo, Eduardo;Moody, Joel;Vermund, Sten H.
目标.描述HTLV-1相关性脊髓病/热带痉挛性下肢轻瘫（HAM/TSP）、类圆线虫病或无症状HTLV-1感染的母亲的后代中HTLV-1感染的频率，并确定与HTLV-1感染相关的因素。在一项描述性研究中，回顾了1989年至2003年在秘鲁利马的一家公立医院接受HTLV感染检测的HTLV-1阳性妇女及其后代的记录。患有类圆线虫病、HAM/TSP或无症状感染的妇女的儿子和女儿符合本研究的条件。包括370例受试者：279例为104例HAM/TSP母亲的后代，58例为22例类圆线虫病母亲的后代，33例为26例无症状母亲的后代。测试时后代的平均年龄为26岁（标准差12）。19%的后代检测为HTLV-1阳性：无症状母亲的后代中为6%（2/33），HAM/TSP母亲的后代中为19%（521279），而患有类圆线虫病的母亲的后代中为31%（18/58）。（a）母乳喂养的持续时间（12至24个月与少于6个月母乳喂养的比值比[OR] = 15.1; [4.2-54.1]）;（B）母亲的临床状况（与无症状母亲的后代相比，HAM/TSP的OR = 8.3 [1.0-65.3]，类圆线虫病的OR = 11.5 [1.4-98.4]）; Q输血史（OR = 5.5 [2.0-15.2]）。除了已知的HTLV-1传播的危险因素（母乳喂养的持续时间和输血史）外，母亲HAM/TSP和类圆线虫病与HTLV-1感染母亲的后代的血清阳性相关。
Objectives. To describe the frequency of HTLV-1 infection among offspring of mothers who had presented with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), strongyloidiasis, or asymptomatic HTLV-1 infection, and to identify factors associated with HTLV-1 infection.Methods. In a descriptive study, records were reviewed of HTLV-1-positive women and their offspring who had been tested for HTLV infection at a public hospital in Lima, Peru, from 1989 to 2003. Sons and daughters of women who had presented with strongyloidiasis, HAM/TSP, or asymptomatic infection were eligible for this study.Results. Three hundred seventy subjects were included: 279 were the offspring of 104 mothers presenting with HAM/TSP, 58 were the offspring of 22 mothers with strongyloidiasis, and 33 were the offspring of 26 asymptomatic mothers. Mean age of the offspring at the time of testing was 26 years (standard deviation 12). Nineteen percent of the offspring tested positive for HTLV-1: 6% (2/33) of those with asymptomatic mothers, 19% (521279) among the offspring of mothers with HAM/TSP, and 31% (18/58) among the offspring of mothers presenting with strongyloidiasis On multiple logistic regression analysis, three factors were significantly associated with HTLV-1: (a) duration of breast-feeding (odds ratio [OR] = 15.1; [4.2-54.1] for 12 to 24 months versus less than 6 months breast-feeding); (b) clinical condition of the mother (OR = 8.3 [1.0-65.3] for HAM/TSP and OR = 11.5 [1.4-98.4] for strongyloidiasis in comparison with offspring of asymptomatic mothers); and Q transfusion history (OR = 5.5 [2.0-15.2]).Conclusions. In addition to known risk factors for HTLV-1 transmission (duration of breast-feeding and history of blood transfusion), maternal HAM/TSP and strongyloidiasis were associated with seropositivity among offspring of HTLV-1-infected mothers.