Endocannabinoid system and alcohol addiction: Pharmacological studies
Endocannabinoid system and alcohol addiction: Pharmacological studies
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DOI：
10.1016/j.pbb.2005.01.022
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Gessa, GL
中科院分区：
文献类型：
--
作者：
Colombo, G;Serra, S;Gessa, GL
本文描述了最近的药理学研究结果，表明大麻素 CB I 受体参与调节酒精消耗和饮酒动机的神经回路。大麻素 CB 受体激动剂被发现可以特异性刺激大鼠的酒精摄入和酒精的动机特性。相反，据报道，大麻素 CB（受体拮抗剂 SR 141716）可特异性抑制大鼠饮酒行为、复发样饮酒和酒精动机特性的获得和维持。最近的数据表明，阿片受体拮抗剂 a) 阻断大麻素对酒精摄入的刺激作用，b) 协同增强 SR 141716 对酒精摄入和酒精动机特性的抑制作用。一致地，SR 141716 阻断吗啡对酒精摄入的刺激作用。这些结果表明，a）大麻素和阿片受体系统在控制酒精摄入和饮酒动机方面存在功能联系，b）新颖且潜在有效的酒精中毒治疗策略可能来自大麻素和阿片受体拮抗剂的组合。 (c) 2005 Elsevier Inc. 保留所有权利。
The present paper describes the results of recent pharmacological studies implicating the cannabinoid CB I receptor in the neural circuitry regulating alcohol consumption and motivation to consume alcohol. Cannabinoid CB, receptor agonists have been found to specifically stimulate alcohol intake and alcohol's motivational properties in rats. Conversely, the cannabinoid CB, receptor antagonist, SR 141716, has been reported to specifically suppress acquisition and maintenance of alcohol drinking behavior, relapse-like drinking and alcohol's motivational properties in rats. More recent data indicate that opioid receptor antagonists a) blocked the stimulatory effect of cannabinoids on alcohol intake, and b) synergistically potentiated the suppressing effect of SR 141716 on alcohol intake and alcohol's motivational properties. Consistently, SR 141716 blocked the stimulatory effect of morphine on alcohol intake. These results suggest a) the existence of a functional link between the cannabinoid and opioid receptor systems in the control of alcohol intake and motivation to consume alcohol, and b) that novel and potentially effective therapeutic strategies for alcoholism may come from the combination of cannabinoid and opioid receptor antagonists. (c) 2005 Elsevier Inc. All rights reserved.