Project ALERT A Cluster Randomized Trial
Project ALERT A Cluster Randomized Trial
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DOI：
10.1001/archpediatrics.2009.88
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发表时间：
2009-07-01
影响因子：
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通讯作者：
Flewelling, Robert L.
中科院分区：
文献类型：
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作者：
Ringwalt, Christopher L.;Clark, Heddy Kovach;Flewelling, Robert L.
目的：为了评估ALERT项目对青少年一生和30天使用香烟、酒精、大麻和吸入剂的影响，设计：整群随机试验。设置：2004年至2008年，来自11个州的学校被纳入2个连续队列。参与者：美国所有公立学校，包括6至8年级，并在6年级招收至少100名学生被招募。在开始这项研究的40所学校中，（每个条件17名）完成了它。分析了5883名独立参与者的数据。干预措施：Project ALERT是一项针对中年级的手动课堂药物使用预防课程，教授给六年级和七年级的学生。主要成果指标：在干预开始之前，作为六年级学生，在完成2年的干预之后，作为七年级学生，对学生进行了调查。结果的措施，包括终身和30天使用的香烟，酒精，大麻，和inhalants.Results：在基线，学生在干预条件下轻微至中度更有可能报告使用的8项措施检查比学生在控制条件。对于除终生吸烟外的所有指标，这些差异在随访时不太明显，因此有利于项目效果。然而，这些变化在统计学上是显著的，只有一个结果指标，过去30天的饮酒（调整后的比值比从基线时的2.07降低到随访时的1.32; P = 0.006）。结论：当我们的目标是六年级人群时，ALERT项目是无效的。
Objective: To evaluate the effects of Project ALERT on adolescents' lifetime and 30-day use of cigarettes, alcohol, marijuana, and inhalants.Design: Cluster randomized trial.Setting: Schools from 11 states were enrolled in 2 successive cohorts from 2004 to 2008.Participants: All public schools in the United States that included grades 6 through 8 and enrolled at least 100 students in sixth grade were recruited. Of the 40 schools that began the study, 34 (17 per condition) completed it. Data were analyzed from 5883 unique participants.Intervention: Project ALERT, a manualized classroom-based substance use prevention curriculum for the middle grades, was taught to sixth and seventh graders.Main Outcome Measures: Students were surveyed before the onset of the intervention, as sixth graders, and after the completion of the 2-year intervention, as seventh graders. Outcome measures included lifetime and 30-day use of cigarettes, alcohol, marijuana, and inhalants.Results: At baseline, students in the intervention condition were slightly to moderately more likely to report use for each of the 8 measures examined than were students in the control condition. For all measures except lifetime use of cigarettes, these differences were less pronounced at follow-up and therefore were in the direction of favorable program effects. These changes were statistically significant, however, for only 1 outcome measure, past 30-day use of alcohol (reduction in the adjusted odds ratio from 2.07 at baseline to 1.32 at follow-up; P = .006).Conclusion: Project ALERT was not effective when delivered to the sixth grade population we targeted.