Spatial learning in deer mice: sex differences and the effects of endogenous opioids and 60 Hz magnetic fields
Spatial learning in deer mice: sex differences and the effects of endogenous opioids and 60 Hz magnetic fields
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鹿鼠的空间学习：性别差异以及内源性阿片类药物和 60 Hz 磁场的影响
DOI：
--
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
T. Perrot
中科院分区：
文献类型：
--
作者：
M. Kavaliers;K. Ossenkopp;F. Prato;D. Innes;L. Galea;D. M. Kinsella;T. Perrot
我们研究了短时间暴露于弱60 Hz极低频（ELF）磁场和阿片系统对生殖成年雄、雌鹿小鼠空间行为和学习的影响。性别差异在空间表现上是明显的，在Morris水迷宫中，雄性鹿鼠比雌性鹿鼠表现出明显更好的表现，在Morris水迷宫中，动物必须获得并保留一个水下隐藏平台的位置。在任务习得过程中，短暂（最多5分钟）暴露于弱（100 μT） 60 Hz的磁场中，显著提高了雌性的表现，消除了任务习得中的性别差异。阿片类拮抗剂纳曲酮也能改善女性的习得，尽管效果明显不如磁场。这些促进效应包括“非空间”（任务熟悉度和相关焦虑/厌恶行为的减少）的改变，也可能包括任务的“空间”方面。脑啡肽酶抑制剂SCH 34826增强脑啡肽活性，显著降低雄鹿小鼠的任务表现。纳曲酮和60hz磁场均能减弱脑啡肽介导的空间表现下降。这些发现表明，短时间暴露在60 Hz磁场下可以增强鹿小鼠的水迷宫任务习得，并表明这些促进空间表现的作用涉及阿片活性的改变。
We examined the effects of brief exposure to weak 60 Hz extremely low frequency (ELF) magnetic fields and opioid systems on spatial behavior and learning in reproductive adult male and female deer mice, Peromyscus maniculatus. Sex differences were evident in spatial performance, with male deer mice displaying significantly better performance than female mice in the Morris water maze, whereby animals had to acquire and retain the location of a submerged hidden platform. Brief (maximum 5 min) exposure to weak (100 μT) 60 Hz magnetic fields during task acquisition significantly improved female performance, eliminating the sex differences in acquisition. The opiate antagonist, naltrexone, also improved female acquisition, though significantly less than the magnetic fields. These facilitatory effects involved alterations of “non-spatial” (task familiarization and reduction of related anxiety/aversive related behaviors) and possibly “spatial” aspects of the task. Enhancement of enkephalin activity with the enkephalinase inhibitor, SCH 34826, significantly reduced task performance by male deer mice. Both naltrexone and the 60 Hz magnetic fields attenuated the enkephalin mediated reductions of spatial performance. These findings indicate that brief exposure to 60 Hz magnetic fields can enhance water maze task acquisition by deer mice and suggest that these facilitatory effects on spatial performance involve alterations in opioid activity.
光周期影响雄性鹿鼠（Peromyscus maniculatus）维持繁殖所需的关键热量摄入。
影响因子：
3.6
作者：
Nelson,RJ;Kita,M;Blom,JM;Rhyne-Grey,J
通讯作者：
Rhyne-Grey,J
阿片拮抗剂可改善空间记忆。
DOI：
10.1126/science.6879198
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gallagher,M;King,RA;Young,NB
通讯作者：
Young,NB