Unveiling Distribution of Per- and Polyfluoroalkyl Substances in Matched Placenta-Serum Tetrads: Novel Implications for Birth Outcome Mediated by Placental Vascular Disruption.
Unveiling Distribution of Per- and Polyfluoroalkyl Substances in Matched Placenta-Serum Tetrads: Novel Implications for Birth Outcome Mediated by Placental Vascular Disruption.
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揭示匹配的胎盘-血清四分体中全氟和多氟烷基物质的分布：胎盘血管破坏介导的出生结局的新含义。
DOI：
10.1021/acs.est.2c09184
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发表时间：
2023-03
影响因子：
11.4
通讯作者：
D. Ji;Yitao Pan;Xuelin Qiu;Jingjin Gong;Xianjie Li;Conying Niu;Jingzhi Yao;Shili Luo;Zhuyi Zhang;Qiong Wang;Jiayin Dai;Yanhong Wei
中科院分区：
文献类型：
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作者：
D. Ji;Yitao Pan;Xuelin Qiu;Jingjin Gong;Xianjie Li;Conying Niu;Jingzhi Yao;Shili Luo;Zhuyi Zhang;Qiong Wang;Jiayin Dai;Yanhong Wei
胎盘对于胎儿发育和许多物质（包括全氟烷基物质和多氟烷基物质（PFAS））的母胎转移至关重要。然而，PFAS在胎盘内的分布及其对胎盘血管功能的影响仍不清楚。在这项研究中，从中国广州收集了 302 个匹配的绒毛膜下胎盘（胎儿侧）、副基底层胎盘（母侧）、脐带血清和母体血清样本的四分体。测量了 18 种新兴和传统 PFAS 以及 5 种胎盘血管生物标志物。结果显示，与副基底层胎盘相比，在绒毛膜下胎盘中检测到更高水平的全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和氯化多氟醚磺酸（Cl-PFESA）。绒毛膜下胎盘中的 PFAS 与胎盘血管生物标志物（高达 32.5%）和较低的出生体重显着相关，但在血清中则不然。出生体重与 PFOA（β：-103.8，95% CI：-186.3 和 -21.32）和 6:2 Cl-PFESA（β：-80.04，95% CI：-139.5 和 -20.61）呈负相关，主要存在于绒毛膜下胎盘中。改变的胎盘血管生成素-2 和血管内皮生长因子受体-2 的调节作用在不良出生结局与胎盘内 PFOS 和 8:2 Cl-PFESA 的关联中得到证实，解释了总效应的 9.5%-32.5%。据我们所知，这项研究首次报告了 PFAS 的胎盘内差异分布和介导不良分娩结局的胎盘血管效应，并为 PFAS 相关健康风险评估中胎盘板特异性测量提供了新的见解。
The placenta is pivotal for fetal development and maternal-fetal transfer of many substances, including per- and polyfluoroalkyl substances (PFASs). However, the intraplacental distribution of PFASs and their effects on placental vascular function remain unclear. In this study, 302 tetrads of matched subchorionic placenta (fetal-side), parabasal placenta (maternal-side), cord serum, and maternal serum samples were collected from Guangzhou, China. Eighteen emerging and legacy PFASs and five placental vascular biomarkers were measured. Results showed that higher levels of perfluorooctanoic (PFOA), perfluorooctane sulfonic acid (PFOS), and chlorinated polyfluorinated ether sulfonic acids (Cl-PFESAs) were detected in subchorionic placenta compared to parabasal placenta. There were significant associations of PFASs in the subchorionic placenta, but not in the serum, with placental vascular biomarkers (up to 32.5%) and lower birth size. Birth weight was negatively associated with PFOA (β: -103.8, 95% CI: -186.3 and -21.32) and 6:2 Cl-PFESA (β: -80.04, 95% CI: -139.5 and -20.61), primarily in subchorionic placenta. Mediation effects of altered placental angiopoietin-2 and vascular endothelial growth factor receptor-2 were evidenced on associations of adverse birth outcomes with intraplacental PFOS and 8:2 Cl-PFESA, explaining 9.5%-32.5% of the total effect. To the best of our knowledge, this study is the first to report on differential intraplacental distribution of PFASs and placental vascular effects mediating adverse birth outcomes and provides novel insights into the placental plate-specific measurement in PFAS-associated health risk assessment.