LPA Promotes T Cell Recruitment through Synthesis of CXCL13.
LPA Promotes T Cell Recruitment through Synthesis of CXCL13.
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DOI：
10.1155/2015/248492
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发表时间：
2015
影响因子：
4.6
通讯作者：
Bourgoin SG
中科院分区：
文献类型：
--
作者：
Hui W;Zhao C;Bourgoin SG
溶血磷脂酸（LPA）是一种具有生物活性的磷脂，通过诱导多种炎性细胞因子/趋化因子的表达和分泌，在多种炎症性疾病中发挥重要作用。在此，我们报告了在小鼠气囊炎症模型中，LPA以时间依赖性方式诱导CXCL 13分泌，并且当在用TNF-α（一种关键的炎症细胞因子）预处理后施用LPA时，反应加剧。LPA介导白细胞的募集，包括将CD 3+细胞募集到未引发和TNF-α引发的气囊中。在向TNF-α致敏的气囊中给予LPA之前，使用注射到气囊中的封闭抗体进行CXCL 13中和，减少了CD 3+细胞的流入。我们的数据强调了LPA介导的CXCL 13分泌在T细胞募集中起作用，并参与炎症反应的调节。
Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and with exacerbation of the response when LPA was administered after a pretreatment with TNF-α, a key inflammatory cytokine. LPA mediates recruitment of leukocytes, including that of CD3+ cells into unprimed and TNF-α-primed air pouches. CXCL13 neutralization using a blocking antibody injected into air pouches prior to administration of LPA into TNF-α-primed air pouches decreased CD3+ cell influx. Our data highlight that LPA-mediated CXCL13 secretion plays a role in T cell recruitment and participates in regulation of the inflammatory response.