Young-age onset of colorectal cancer in Israel
Young-age onset of colorectal cancer in Israel
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DOI：
10.1007/s10151-009-0501-7
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Ziv, Y.
中科院分区：
文献类型：
--
作者：
Neufeld, D.;Shpitz, B.;Ziv, Y.
该研究旨在调查年轻发病（50岁）与晚发性以色列结直肠癌患者（50岁）在临床病理、种族和人口统计学表现以及错配修复蛋白表达方面的差异。从病历和病理报告中回顾性收集结直肠癌患者的临床、人口统计学和组织病理学资料。90例年龄在50岁以下，平均年龄为42岁的患者与190例年龄在50岁以上的患者进行比较（见表1）。年轻发病的患者中60%是女性，而老年组中为40% （P = 0.02）。21%的年轻发病患者是阿拉伯人，而2%的老年发病患者是阿拉伯人（P = 0.001）。年轻患者黏液癌的比例更高，在疾病晚期诊断的比例更高；40%的年轻起病患者和31%的老年起病患者呈现杜克C期和D期（P = 0.02）。在我们的以色列患者队列中，较年轻的结直肠癌发病年龄与较高的阿拉伯患者百分比、黏液癌、女性和诊断时的晚期相关。
The study was conducted to investigate the differences in clinical-pathological, ethnic, and demographic presentations and the expression of mismatch repair proteins in a cohort of young-onset (a parts per thousand currency sign50 years) versus late-onset Israeli patients (> 50 years) with colorectal cancer.Clinical, demographic, and histopathological data of patients with colorectal cancer were collected retrospectively from medical records and pathology reports.Ninety patients, 50 years of age or younger with a mean age of 42 years were compared with a group of 190 patients above 50 years of 50 (see Table 1). Sixty percent of the young-onset patients were females, compared to 40% in the older age group (P = 0.02). Twenty-one percent of the young-onset patients were Arabs as compared to 2% of older-onset patients (P = 0.001). Younger patients displayed a higher percentage of mucinous cancers and a higher percentage of diagnosis at an advanced stage of disease; 40% of young-onset versus 31% of older-onset patients presented Duke's stages C and D (P = 0.02).Younger age of onset colorectal cancer in our cohort of Israeli patients is associated with higher percentage of Arab patients, mucinous cancers, female gender, and advanced stage at diagnosis.