Dosimetry considerations in phototherapy.
Dosimetry considerations in phototherapy.
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DOI：
10.1118/1.594932
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发表时间：
1981-03
期刊：
影响因子：
3.8
通讯作者：
A. Profio;D. Doiron
中科院分区：
文献类型：
--
作者：
A. Profio;D. Doiron
光疗中的剂量测定涉及确定每单位质量组织吸收的能量，并针对光化学反应中的量子产率进行校正。血卟啉衍生物与可见光联合光化学治疗癌症的剂量率与消光系数、单线态氧产生的量子产率、敏化剂浓度和深部能流密度有关。给出了确定这些量的数据或方法。计算已经进行了在深度的能量通量密度，作为总衰减系数和散射系数与总衰减系数之比的函数，在平板几何形状的各向同性散射。对于较小的吸收，这些深度剂量曲线在组织内表现出最大值，然后呈指数下降。
Dosimetry in phototherapy involves a determination of the energy absorbed per unit mass of tissue, corrected for the quantum yield in a photochemical reaction. The dose rate in photochemotherapy of cancer with hematoporphyrin derivative and visible light is related to the extinction coefficient, quantum yield for singlet oxygen production, concentration of sensitizer and energy flux density at depth. Data or methods of determining these quantities are presented. Calculations have been performed for the energy flux density at depth, as a function of the total attenuation coefficient and ratio of scattering coefficient to total attenuation coefficient, for isotropic scattering in slab geometry. For small absorption, these depth dose curves exhibit a maximum within the tissue followed by an exponential decrease.