Comparative Effects of Sesame Seeds Differing in Lignan Contents and Composition on Fatty Acid Oxidation in Rat Liver
Comparative Effects of Sesame Seeds Differing in Lignan Contents and Composition on Fatty Acid Oxidation in Rat Liver
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DOI：
10.5650/jos.ess14182
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发表时间：
2015-02-01
影响因子：
1.5
通讯作者：
Ogata, Naoki
中科院分区：
文献类型：
--
作者：
Ide, Takashi;Azechi, Ayana;Ogata, Naoki
我们比较了富含木酚素的三个品种（Gomazou、Maruhime 和 Maruemon）芝麻与传统品种（Masekin）芝麻在大鼠体内的生理活性。 Gomazou、Maruhime 和 Maruemon 品种种子中的脂溶性木脂素（芝麻素和芝麻林）值之和约为 Masekin 值的两倍。丸右卫门种子所含的脂溶性木脂素主要为芝麻素，而其他品种则含有芝麻素和芝麻林素，比例约为 2:1。经过 16 天的实验，在实验日粮中添加 200 g/kg 芝麻，增加了脂肪酸氧化酶的活性和 mRNA 水平。富含木脂素的种子比来自马塞金的种子的增加更强烈。相反，芝麻降低了脂肪生成酶的活性和 mRNA 水平。然而，所有品种的芝麻对这些参数的影响是相似的。饲喂含有富含木酚素的芝麻的饮食的大鼠的血清三酰甘油浓度低于饲喂不含芝麻的饮食或含有马塞金品种种子的饮食的大鼠。喂食含有富含木酚素的芝麻的饮食的大鼠的血清丙二醛（脂质过氧化的标志物）低于喂食无芝麻饮食或马塞金饮食的大鼠。显然，无论木脂素成分如何，富含木脂素的芝麻都会更深刻地影响肝脏脂肪酸氧化和血清三酰甘油水平，并可能减弱氧化应激。因此，食用富含木酚素的芝麻有望产生促进健康的生理活性。
We compared the physiological activities of sesame seeds rich in lignans from three varieties (Gomazou, Maruhime and Maruemon), and those from a conventional cultivar (Masekin) in rats. The sum of the values of fat-soluble lignans (sesamin and sesamolin) in seeds of Gomazou, Maruhime and Maruemon varieties was approximately double the value in Masekin. Seeds from Maruemon contained fat-soluble lignan most exclusively as sesamin while other varieties contained sesamin and sesamolin at about a 2:1 ratio. After a 16 d experiment, sesame seeds, added at 200 g/kg to the experimental diets, increased the activity and mRNA levels of fatty acid oxidation enzymes. Increases were stronger with seeds rich in lignans than with seeds from Masekin. In contrast, sesame seeds lowered the activity and mRNA levels of lipogenic enzymes. However, sesame seeds from all the varieties were comparable in affecting these parameters. Serum triacylglycerol concentrations were lower in rats fed diets containing sesame seeds rich in lignans than in those fed a diet free of sesame seeds or a diet containing seeds from the Masekin variety. Serum malondialdehyde (a marker of lipid peroxidation) was lower in rats fed diets containing sesame seeds rich in lignans than in those fed a sesame seed-free diet or Masekin diet. It is apparent that sesame seeds rich in lignans, irrespective of lignan composition, more profoundly affect hepatic fatty acid oxidation and serum triacylglycerol levels and possibly attenuate oxidative stress. Therefore, consumption of sesame seeds rich in lignans hopefully results in physiological activity to promote health.