Effects and safety of granulocyte colony-stimulating factor in healthy volunteers.
Effects and safety of granulocyte colony-stimulating factor in healthy volunteers.
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DOI：
10.1097/moh.0b013e328319913c
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发表时间：
2009-01
影响因子：
3.2
通讯作者：
Anderlini P
中科院分区：
文献类型：
--
作者：
Anderlini P
重组人粒细胞集落刺激因子（rhG-CSF）是目前广泛应用于正常供者外周血造血祖细胞（PBPC）的采集和粒细胞的输注。目前可用的数据的生物学和分子效应，和安全性的rhG-CSF在正常健康志愿者进行审查。除了其对中性粒细胞动力学和功能状态的已知激活作用外，rhG-CSF给药可影响单核细胞、淋巴细胞和止血系统。G-CSF受体在多种非髓样组织中被鉴定，尽管它们的作用和功能活性并不总是被很好地定义。此外，rhG-CSF能够调节复杂的细胞因子网络，并可影响炎症反应。除了已知的PBPC动员作用外，rhG-CSF还可以动员树突状细胞和内皮祖细胞。在临床水平上，严重rhG-CSF相关不良事件已得到充分描述（例如脾破裂），但仍然罕见。rhG-CSF在健康志愿者中的作用，虽然通常是短暂的和自限性的，但现在认为比以前认为的更复杂和异质。虽然rhG-CSF给药健康志愿者继续有一个有利的风险效益概况，这些新的发现有保障正常人的安全性的影响。
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now widely used in normal donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion. Currently available data on biologic and molecular effects, and safety of rhG-CSF in normal healthy volunteers are reviewed. In addition to its known activating role on neutrophil kinetics and functional status, rhG-CSF administration can affect monocytes, lymphocytes and the hemostatic system. G-CSF receptors were identified in a variety of non-myeloid tissues, although their role and functional activity have not always been well defined. Moreover, rhG-CSF is capable of modulating complex cytokine networks and can impact the inflammatory response. In addition to its known mobilizing role for PBPCs, rhG-CSF can mobilize dendritic and endothelial progenitor cells as well. On a clinical level, serious rhG-CSF-related adverse events are well described (e.g. splenic rupture) but remain rare. rhG-CSF effects in healthy volunteers, while normally transient and self-limiting, are now believed to be more complex and heterogeneous that previously thought. While rhG-CSF administration to healthy volunteers continues to have a favorable risk-benefit profile, these new findings have implications for safeguarding the safety of normal individuals.