Epigenetic and small RNA regulation of senescence
Epigenetic and small RNA regulation of senescence
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DOI：
10.1007/s11103-012-0005-0
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发表时间：
2013-01
影响因子：
5.1
通讯作者：
K. Humbeck
中科院分区：
文献类型：
--
作者：
K. Humbeck
叶片衰老是通过一个复杂的调控网络进行调控的，该网络由内部和外部信号触发，用于基因表达的重编程。在植物中，主要的发育阶段转换和胁迫反应受表观遗传控制。在这篇综述中，基本的分子机制进行了简要的讨论，证据表明，表观遗传过程也参与了叶片衰老的调节。衰老过程中染色质结构的变化，差异组蛋白修饰决定衰老相关基因和DNA甲基化的活性和非活性位点。此外，小RNA在衰老调控中的作用进行了讨论。
Leaf senescence is regulated through a complex regulatory network triggered by internal and external signals for the reprogramming of gene expression. In plants, the major developmental phase transitions and stress responses are under epigenetic control. In this review, the underlying molecular mechanisms are briefly discussed and evidence is shown that epigenetic processes are also involved in the regulation of leaf senescence. Changes in the chromatin structure during senescence, differential histone modifications determining active and inactive sites at senescence-associated genes and DNA methylation are addressed. In addition, the role of small RNAs in senescence regulation is discussed.