Detection, characterization and identification of phenolic acids in Danshen using high-performance. liquid chromatography with diode array detection and electrospray ionization mass spectrometry
Detection, characterization and identification of phenolic acids in Danshen using high-performance. liquid chromatography with diode array detection and electrospray ionization mass spectrometry
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DOI：
10.1016/j.chroma.2007.05.081
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发表时间：
2007-08-17
影响因子：
4.1
通讯作者：
Guo, De-An
中科院分区：
文献类型：
--
作者：
Liu, Ai-Hua;Guo, Hui;Guo, De-An
采用阴离子模式下的高效液相-二极管阵列检测-电喷雾离子陷阱串联质谱仪(HPLC-DAD-ESI-MSN)对丹参中11种酚酸类化合物的裂解途径进行了分析。对丹参提取物进行了分析，首次鉴定或初步鉴定了42种酚酸类化合物，其中包括16种新的次要成分。报道了一种新的固相萃取(SPE)方法、新的高效液相分离方法、新的液相色谱(LC)-MS和LC-MSN(n=3-5)数据和建议的裂解途径，以及酚酸的LC保留时间。(C)2007 Elsevier B.V.保留所有权利。
By using HPLC-diode array detection-electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MSn) in negative ion mode, we have analyzed the fragmentation pathways of 11 phenolic acids which were isolated from Danshen. Then the extract of Danshen was analyzed, and a total of 42 phenolic acids, including sixteen new minor constituents, were identified or tentatively identified for the first time. A new solidphase extraction (SPE) method, new HPLC separation method, new liquid chromatography (LC)-MS and LC-MSn (n = 3-5) data and proposed fragmentation pathways, LC retention time for phenolic acids are reported. (c) 2007 Elsevier B.V. All rights reserved.