Involvement of neuromedin S in the oxytocin release response to suckling stimulus
Involvement of neuromedin S in the oxytocin release response to suckling stimulus
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DOI：
10.1016/j.bbrc.2008.07.124
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发表时间：
2008-10-10
影响因子：
3.1
通讯作者：
Murakami, Noboru
中科院分区：
文献类型：
--
作者：
Sakamoto, Takumi;Mori, Kenji;Murakami, Noboru
我们最近发现来自大鼠下丘脑的神经介质S （NMS）是与神经介质u不同的FM-4/TGR-1受体的内源性配体。在本研究中，我们研究了NMS在大鼠幼鼠哺乳刺激下催产素释放反应中的作用。脑室内注射NMS诱导室旁核和视上核中cFos的表达。双免疫组化分析显示，在两个核的一部分催产素能神经元中诱导了cFos的表达。此外，静脉注射NMS刺激完整大鼠的催产素释放密切依赖，并增加泌乳大鼠的泌乳量。另一方面，在哺乳期大鼠体内注射抗nms抗血清可明显抑制哺乳诱导的泌乳。这些结果提示，在大鼠哺乳刺激下，内源性NMS在催产素释放反应中起重要作用。(C) 2008年Elsevier Inc.出版
We recently identified neuromedin S (NMS) from the rat hypothalamus as an endogenous ligand for the FM-4/TGR-1 receptor distinct from neuromedin U. In the present study we examined the role of NMS in, the oxytocin release response to suckling stimulation by rat pups. Intracerebroventricular (icv) injection of NMS induced cFos expression in the paraventricular nucleus and supraoptic nucleus. Double immunohistochemical analysis revealed induction of cFos expression in a proportion of oxytocinergic neurons in both nuclei. In addition, icv injection of NMS stimulated oxytocin release close-dependently in intact rats, and increased milk secretion in lactating rats. On the other hand, icv injection of anti-NMS antiserum into lactating rats significantly suppressed suckling-induced milk ejection. These results Suggest that, in the rat, endogenous NMS plays an important role in the oxytocin release response to the suckling stimulus. (C) 2008 Published by Elsevier Inc.