The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study.
The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study.
复制标题
小鼠气管支气管上皮细胞：定量光学和电子显微镜研究。
作者：
R. Pack;L. Al;G. Morris
小鼠传导气道的上皮由单层细胞组成。这些细胞的数量，类型和形式进行了研究，在五个气道水平从气管到远端传导支气管与光镜和电镜。与在其他物种中发现的相反，鼠气道上皮中的大多数（50 - 60%）细胞是Clara细胞。粘液产生组织在整个气道中并不常见，但在隆突和主支气管中上皮粘液细胞的数量增加。小叶内气道未见粘液或浆液细胞或粘膜下腺体。在形态学的基础上，Clara细胞被识别为三种不同的形式。有时，观察到的细胞显然是这些之间的过渡类型，也克拉拉细胞和粘液或纤毛细胞之间。有人建议，“转化”细胞可能表明克拉拉细胞作为一个发育细胞参与上皮细胞营业额的作用。还提供证据表明，克拉拉细胞可能经历顶浆分泌和部分分泌，有人认为，后者可能是PAS + VE材料。上皮内未见游离神经末梢。这可能与小鼠咳嗽的能力受到限制有关。这表明，粘液产生组织和咳嗽反射的缺乏可能是由于小鼠气道直径小。
The epithelium of the conducting airways of the mouse consists of a single layer of cells. The number, type and form of these cells have been investigated at five airway levels from the trachea to the distal conducting bronchi with both light and electron microscopes. Contrary to what is found in other species, the majority (50-60%) of cells in the murine airway epithelium are Clara cells. Mucus-producing tissue was infrequent throughout the airways, though epithelial mucous cells occurred in increased numbers at the carina and in the primary bronchus. No mucous or serous cells or submucosal glands were seen in intralobular airways. On a morphological basis, three distinct forms of Clara cell were recognized. On occasion, cells were observed which were apparently transitional types between these and also between Clara cells and mucous or ciliated cells. It is suggested that the 'transforming' cells may indicate a role for the Clara cell as a developmental cell involved in the epithelial cell turnover. Evidence is also provided that Clara cells may undergo both apocrine and merocrine secretion and, it is argued that the latter may be of a PAS + ve material. Free nerve endings were not seen in the epithelium. This may be related to athe restricted ability of mice to cough. It is suggested that the lack of mucus-producing tissue and of cough reflex may be due to the small diameter of the mouse airways.