Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis
Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis
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DOI：
10.1148/radiol.2333020981
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发表时间：
2004-12-01
期刊：
影响因子：
19.7
通讯作者：
Brown, WR
中科院分区：
文献类型：
--
作者：
Moody, DM;Thore, CR;Brown, WR
目的：调查血管密度的变化，随着年龄的增长，在三个领域的大脑和相关的这些变化与脑白质疏松症（LA）的磁共振（MR）图像和位置的基础上，在深白色物质（WM）。材料和方法：内部审查委员会的批准或知情同意，从近亲是不需要的。21名受试者（平均年龄72.5岁; 12名男性，9名女性）的大脑在尸检时进行了MR成像评价。左心房的存在是由深部白质的高信号融合或斑片状区域指示的。LA患者的微血管密度（血管面积除以总面积的百分比）通过计算机形态学分析测量LA病变、MR成像中健康的WM和皮质。将这些测量值相互比较，并与健康受试者相应区域的测量值进行比较。传入血管在火棉胶切片中用碱性磷酸酶染色。一系列的重复测量线性混合models.Results的计算进行了测试的假设：尸检大脑从12个受试者LA（平均年龄，72岁，6名男性，6名女性）和9个受试者没有LA（平均年龄，73岁，6名男性，3名女性）进行了研究。左心房深部白质病变的传入微血管密度+/-标准差（2.56%+/-1.56）显著低于健康受试者相应的深部白质病变（3.20%+/-1.82）（P= 0.018）。与LA的主题表现出减少传入血管密度在早期的年龄在所有三个领域的大脑时，与健康受试者的相同age.Conclusion：结果的传入血管密度减少的面积LA和病变外表明，LA是一个广义的脑血管疾病的过程，而不是一个局限于深部WM。(C)RSNA，2004年。
Purpose: To investigate vessel density changes with increasing age in three areas of the brain and to correlate these changes with leukoaraiosis (LA) on the basis of magnetic resonance (MR) images and location in deep white matter (WM).Materials and Methods: Internal review board approval or informed consent from next of kin was not required. Brains of 21 subjects (mean age, 72.5 years; 12 men, nine women) were evaluated at autopsy with MR imaging. The presence of LA was indicated by confluent or patchy areas of hyperintensity in deep WM. Microvascular density (percentage of vessel area divided by total area) in subjects with LA was measured with computerized morphometric analysis in LA lesions, healthy-appearing WM at MR imaging, and the cortex. These measurements were compared with each other and with measurements from corresponding areas in healthy subjects. Afferent vasculature was stained with alkaline phosphatase in celloidin sections. Hypotheses were tested with computation of a series of repeated-measures linear mixed models.Results: Autopsy brains from 12 subjects with LA (mean age, 72 years; six men, six women) and nine subjects without LA (mean age, 73 years; six men, three women) were studied. Afferent microvascular density +/- standard deviation in LA lesions in deep WM (2.56%+/-1.56) was significantly lower than that in corresponding deep WM of healthy subjects (3.20%+/-1.82) (P=.018). Subjects with LA demonstrated decreased afferent vascular density at early ages in all three areas of the brain when compared with healthy subjects of the same age.Conclusion: Findings of decreased afferent vascular density in the area of LA and outside the lesion indicate that LA is a generalized cerebrovascular disease process rather than one confined to deep WM. (C) RSNA, 2004.