Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror
Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror
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DOI：
10.1364/oe.14.001027
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发表时间：
2006-02-06
期刊：
影响因子：
3.8
通讯作者：
Gu, M
中科院分区：
文献类型：
--
作者：
Fu, L;Jain, A;Gu, M
双光子荧光和二次谐波显微技术使在体功能和形态成像成为可能。然而，这些技术在活体动物上的应用受到了工作台上的大体积光学装置的限制。幸运的是，光纤设备日益增长的功能和扫描镜的小型化刺激了发展非线性光学内窥镜的竞赛。在本文中，我们报道了一种基于双包层光子晶体光纤和MEMS反射镜的非线性光学内窥镜原型，该光纤内窥镜用于提高检测效率，并在光纤尖端引导光。小型化的光纤非线性显微镜以大鼠食道成像为特征。来自大鼠尾腱和食道的线条轮廓证明了这项技术在活体应用中的潜力。(C)2006年美国光学学会。
Two-photon fluorescence and second harmonic generation microscopy have enabled functional and morphological in vivo imaging. However, in vivo applications of those techniques to living animals are limited by bulk optics on a bench top. Fortunately, growing functionality of fiber-optic devices and miniaturization of scanning mirrors stimulate the race to develop nonlinear optical endoscopy. In this paper, we report on a prototype of a nonlinear optical endoscope based on a double-clad photonic crystal fiber to improve the detection efficiency and a MEMS mirror to steer the light at the fiber tip. The miniaturized fiber-optic nonlinear microscope is characterized by rat esophagus imaging. Line profiles from the rat tail tendon and esophagus prove the potential of the technology in in vivo applications. (c) 2006 Optical Society of America.