Intracellular survival of Shigella
Intracellular survival of Shigella
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DOI：
10.1111/j.1462-5822.2005.00652.x
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发表时间：
2006-02
影响因子：
3.4
通讯作者：
Michinaga Ogawa;C. Sasakawa
中科院分区：
文献类型：
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作者：
Michinaga Ogawa;C. Sasakawa
细菌入侵真核细胞以及宿主对入侵细菌的识别和杀伤是决定细菌感染命运的关键问题。一旦进入宿主细胞，病原菌通常会改变吞噬体区室或进入宿主细胞质以逃离裂解区室并获得复制生态位。然而，胞质入侵者由宿主先天免疫系统监测，例如由Nod/CARD家族蛋白介导，其通过NF-κB的活化诱导炎症反应。此外，最近的研究表明，自噬，一个主要的细胞质降解系统，消除胞浆蛋白和细胞器，也承认入侵细菌。事实上，除非它们能够绕过自噬膜的捕获，否则自噬靶向的细菌最终通过递送到自溶酶体中而降解。在这篇文章中，我们回顾了志贺氏菌感染上皮细胞的策略的最新进展，然后集中在最近的研究一个有趣的细菌生存策略对自噬降解。
Bacterial invasion of eukaryotic cells and host recognition and killing of the invading bacteria are a key issue in determining the fate of bacterial infection. Once inside host cells, pathogenic bacteria often modify the phagosomal compartment or enter the host cytosol to escape from the lytic compartment and gain a replicative niche. Cytosolic invaders, however, are monitored by host innate immune systems, such as mediated by Nod/CARD family proteins, which induce inflammatory responses via activation of NF‐κB. Furthermore, recent studies indicate that autophagy, a major cytoplasmic degradation system that eliminates cytosolic protein and organelles, also recognizes invading bacteria. Indeed, unless they are able to circumvent entrapping by autophagic membranes, bacteria targeted by autophagy ultimately undergo degradation by delivery into autolysosomes. In this article, we review recent advances in understanding of Shigella strategies to infect epithelial cells, and then focus on recent studies of an intriguing bacterial survival strategy against autophagic degradation.