Cognitive function in cancer survivors: analysis of the 1999-2002 National Health and Nutrition Examination Survey.
Cognitive function in cancer survivors: analysis of the 1999-2002 National Health and Nutrition Examination Survey.
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DOI：
10.1007/s00520-015-2992-2
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
van Wijngaarden E
中科院分区：
文献类型：
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作者：
Williams AM;Janelsins MC;van Wijngaarden E
Cancer and its treatment may affect cognitive function through a number of direct and indirect pathways including inflammation, lipid metabolism, vascular damage, and changes in the blood brain barrier. While short-term treatment-related cognitive changes are well recognized, only limited research is available in older, long-term survivors of cancer. Using NHANES data from 1999 through 2002, 408 cancer survivors and 2,639 non-cancer participants age 60 and above were identified. Cognitive function of these groups were compared using the Digit Symbol Substitution Test (DSST) and self-reported problems with memory or confusion. After adjustment for covariates, cancer survivors scored, on average, 1.99 points lower on the DSST compared to non-cancer survivors (−1.99, 95%CI −3.94, −0.05) Cancer survivors also had 17% higher odds of self-reporting problems with memory or confusion (OR 1.17, 95%CI 0.89, 1.53). In this nationally-representative sample of older U.S. adults, cancer survivors had lower DSST scores than non-survivors and had more self-reported problems with memory or confusion.
