STUDIES ON THE NEURAMINIDASE OF INFLUENZA VIRUS. II. ADDITIONAL PROPERTIES OF THE ENZYMES FROM THE ASIAN AND PR 8 STRAINS.
STUDIES ON THE NEURAMINIDASE OF INFLUENZA VIRUS. II. ADDITIONAL PROPERTIES OF THE ENZYMES FROM THE ASIAN AND PR 8 STRAINS.
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流感病毒神经氨酸酶的研究。
DOI：
10.1016/0003-9861(63)90432-6
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发表时间：
1963
影响因子：
3.9
通讯作者：
V. W. Wilson
中科院分区：
文献类型：
--
作者：
M. Rafelson;M. Schneir;V. W. Wilson
从流感病毒的亚洲株和PR 8株纯化的神经氨酸酶的性质的比较显示了许多差异。这些酶对N-乙酰神经氨酸乳糖的Km值、对竞争性底物N-乙酰神经氨酸的KI值、热稳定性和对许多底物的最佳pH值不同。初步研究表明，这两种酶是免疫学上可区分的，特异性抗血清对酶作用的中和程度取决于所用的底物。
A comparison of the properties of purified neuraminidases from the Asian and PR 8 strains of influenza virus has shown a number of differences. The enzymes differ in theirKMvalues forN-acetylneuraminyllactose, in theirKIvalues for the competitive inhibitorN-acetylneuraminic acid, in heat stability, and in their pH optimum for a number of substrates. Preliminary studies indicate that the two enzymes are immunologically distinguishable, and the degree of neutralization of enzyme action by specific antiserum is dependent on the substrate employed.