Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation
Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation
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DOI：
10.15114/smj.86.45
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发表时间：
2017-12
影响因子：
1.1
通讯作者：
Masaki Yamamoto;T. Hori;N. Hatakeyama;Keita Igarashi;N. Inazawa;N. Suzuki;Norio Takei;Y. Ito;Kimikazu Matsumoto;Koji Kato;H. Tsutsumi;Y. Kokai
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文献类型：
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作者：
Masaki Yamamoto;T. Hori;N. Hatakeyama;Keita Igarashi;N. Inazawa;N. Suzuki;Norio Takei;Y. Ito;Kimikazu Matsumoto;Koji Kato;H. Tsutsumi;Y. Kokai
为了探讨趋化因子（C-C基序）配体8 （CCL8）作为急性移植物抗宿主病（aGVHD）的潜在生物标志物的作用，我们回顾性分析了31例II-IV级aGVHD患者的血清和临床病程。10例血清CCL8浓度低于213 pg/mL的患者无死亡，而21例血清CCL8浓度高于213 pg/mL的患者中有11例在移植后180天内死亡。这项具有里程碑意义的分析显示，血清CCL8浓度大于213 pg/mL的患者生存率显著降低。因此，移植后100天前血清CCL8浓度升高可能预测aGVHD的预后。（2017年10月13日收稿，2017年11月22日收稿）
To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versushost disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II–IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower survival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis. (Received October 13, 2017 and Accepted November 22, 2017)