Preparation and characterization of a novel gelatin-poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial-antioxidant wound-dressing applications
Preparation and characterization of a novel gelatin-poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial-antioxidant wound-dressing applications
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DOI：
10.1002/app.45351
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发表时间：
2017-10-15
影响因子：
3
通讯作者：
Dadfar, Seyed Mohammad Mahdi
中科院分区：
文献类型：
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作者：
Kavoosi, Gholamreza;Bordbar, Zarrintaj;Dadfar, Seyed Mohammad Mahdi
本研究旨在评估富含扎塔利亚精油 (ZO) 的聚乙烯醇 (PVA)、明胶和 PVA-明胶分散体和薄膜的特性。结果表明，在聚合物基体中添加 ZO 后，分散体的电位、粒径、粘度值以及抗氧化和抗菌活性发生显着变化。分散体性质的变化表明 PVA 或明胶与 ZO 之间存在相互作用。这种相互作用可能会影响薄膜的机械和防水性能。 ZO导致薄膜的拉伸强度、弹性模量和溶胀显着降低，而断裂伸长率、溶解度和水蒸气渗透性增加。扫描电子显微镜分析证明了ZO对薄膜形貌的影响，从而影响薄膜的性能，包括机械性能和阻水性能。由于疏水性 ZO 聚集体，向聚合物中添加 ZO 会导致薄膜微观结构变得粗糙，从而在薄膜基质中产生不连续性。 ZO 显着提高了分散体的抗氧化和抗菌活性。铜绿假单胞菌是耐药性最强的细菌。 PVA-ZO和明胶-ZO的抗氧化和抗菌活性得到改善，表明此类产品可以有效地用作伤口敷料。 (c) 2017 年 Wiley periodicals, Inc. J. Appl。聚合物。科学。 2017, 134, 45351。
This study was performed to evaluate the properties of poly(vinyl alcohol) (PVA), gelatin, and PVA-gelatin dispersions and films enriched with Zataria multiflora essential oil (ZO). The results reveal that the potential, particle size, and viscosity values and the antioxidant and antibacterial activities of the dispersions changed significantly with the addition of ZO to the polymer matrix. Changes in the properties of the dispersions suggested the presence of interactions between PVA or gelatin and ZO. Such interactions could affect the mechanical and water-barrier properties of the films. ZO induced remarkable decreases in the tensile strength, elastic modulus, and swelling and increases in the elongation at break, solubility, and water-vapor permeability of the films. Scanning electron microscopy analyses proved the impact of ZO on the film morphology, which affected the film properties, including the mechanical and water-barrier properties. The addition of ZO to the polymer led to a coarse film microstructure because of the hydrophobic ZO aggregates, which produced discontinuities in the film matrix. ZO considerably increased the antioxidant and antibacterial activities of the dispersions. Pseudomonas aeruginosa was the most resistant bacteria. The improved antioxidant and antimicrobial activities of the PVA-ZO and gelatin-ZO indicated that such products could effectively be used as wound dressings. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45351.