Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients
Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients
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DOI：
10.4161/isl.20857
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发表时间：
2012-05-01
期刊：
影响因子：
2.2
通讯作者：
Montet, Xavier
中科院分区：
文献类型：
--
作者：
Botsikas, Diomidis;Terraz, Sylvain;Montet, Xavier
需要一种非侵入性的方法来对人类胰岛的质量和/或功能进行成像，以监测糖尿病的进展和治疗干预的效果。到目前为止，还没有一种方法可以用于人体原位胰岛。动物和体外研究证明，锰输注可以改善胰腺内分泌的磁共振成像（MRI）。在这里，我们测试了类似的方法是否可以区分糖尿病和非糖尿病患者。在体外，人类分离的胰岛很容易吸收锰。在体内，我们回顾了243例锰增强磁共振成像（MEMRI）检查，其中包括24例2型糖尿病患者的41例检查和119例血糖正常患者的202例检查。结果表明，MEMRI基于胰腺的信号增强来区分2型糖尿病患者和非糖尿病患者。
A non-invasive method to image the mass and/or function of human pancreatic islets is needed to monitor the progression of diabetes, and the effect of therapeutic interventions. As yet, no method is available for this purpose, which could be applied to in situ human islets. Animal and in vitro studies have documented that manganese infusion could improve the magnetic resonance imaging (MRI) of the endocrine pancreas. Here, we have tested whether a similar approach could discriminate diabetic and non-diabetic patients. In vitro, human isolated islets readily incorporated manganese. In vivo, 243 manganese-enhanced magnetic resonance imaging (MEMRI) examinations were reviewed, including 41 examinations which were run on 24 patients with type 2 diabetes and 202 examinations which were run on 119 normoglycemic patients. The results show that MEMRI discriminates type 2 diabetics from non-diabetic patients, based on the signal enhancement of pancreas.