HEPATOCELLULAR-CARCINOMA AND CIRRHOSIS IN 146 PATIENTS - LONG-TERM RESULTS OF PERCUTANEOUS ETHANOL INJECTION
HEPATOCELLULAR-CARCINOMA AND CIRRHOSIS IN 146 PATIENTS - LONG-TERM RESULTS OF PERCUTANEOUS ETHANOL INJECTION
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DOI：
10.1148/radiology.197.1.7568806
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发表时间：
1995-10-01
期刊：
影响因子：
19.7
通讯作者：
ZUCCHI, A
中科院分区：
文献类型：
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作者：
LIVRAGHI, T;GIORGIO, A;ZUCCHI, A
目得：确定肝细胞癌（HCC）和肝硬化患者经皮无水乙醇注射（PEI）的适应症。材料和方法：确定746例接受PEI的患者的生存率（567名男性，179名女性;平均年龄，64.3岁;平均随访，36个月）。在Child A（n = 293）、B（n = 149）或C（n = 20）肝硬化和单个5 cm或更小的HCC患者中，3-5年生存率分别为47%-79%、29%-63%和0%-12%。Child A型肝硬化患者中，多发性HCC为36%-68%（n = 121），单发大于5 cm HCC为30%-53%（n = 28），晚期HCC为0%-16%（n = 16）。治疗与1.7%的严重并发症率和0.1%的死亡率。结论：PEI被证明是安全的，有效的，可重复的，成本低。PEI后的生存率与手术后相当，可能是因为手术的更大的激进性和PEI的早期死亡率和肝损伤之间的平衡。
PURPOSE: To define indications for percutaneous ethanol injection (PEI) in patients with hepatocellular carcinoma (HCC) and cirrhosis.MATERIALS AND METHODS: Survival rates were determined in 746 patients who had undergone PEI (567 men, 179 women; mean age, 64.3 years; mean follow-up, 36 months).RESULTS: In patients with Child A (n = 293), B (n = 149), or C (n = 20) cirrhosis and single HCCs 5 cm or smaller, the 3-5-year survival rate was 47%-79%, 29%-63%, and 0%-12%, respectively. In patients with Child A cirrhosis, it was 36%-68% for multiple HCCs (n = 121), 30%-53% for single HCCs larger than 5 cm (n = 28), and 0%-16% for advanced HCC (n = 16). Treatment was associated with a 1.7% rate of severe complications and a 0.1% mortality rate.CONCLUSION: PEI proved safe, effective, and repeatable and had a low cost. Survival after PEI was comparable to that after surgery, probably because of a balancing between greater radicality of surgery and absence of early mortality and liver damage of PEI.