Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study
Worldwide Age at Onset of Female Breast Cancer: A 25-Year Population-Based Cancer Registry Study
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DOI：
10.1038/s41598-019-50680-5
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发表时间：
2019-10-01
影响因子：
4.6
通讯作者：
Serraino, Diego
中科院分区：
文献类型：
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作者：
Bidoli, Ettore;Virdone, Saverio;Serraino, Diego
在低/中等收入国家中观察到早发女性乳腺癌（BC）的发生率高于高收入国家。我们使用全球所有基于人群的癌症登记处（CR）的数据量化了人口老龄化对这种模式的作用。针对五大洲癌症发病率第VI卷（1983-1987年）至第XI卷（2008-2012年）中列出的CR，提取了BC发作时患者的中位年龄和一般人群的中位年龄。通过线性回归模型在横截面水平上评估其相关性，并纵向考虑研究开始和结束时列出的长期CR中人群的25岁老龄化。在2008-2012年期间，人口老龄化每增加一年，BC诊断年龄就增加近1/2年。人口统计学解释了BC年龄差异的42%。1983-1987年，不列颠哥伦比亚省中位年龄低于61.8岁的长期CR显示，25岁后不列颠哥伦比亚省的年龄增加。在世界范围内，BC诊断时的年龄基本上反映了人群的中位年龄。BC检测方法的变化可能会减少这种关联。尽管如此，年轻人群中BC绝对数量的增加值得采取BC预防策略。
A higher frequency of early onset female breast cancers (BC) has been observed in low/middle income countries than in high income countries. We quantified the role of population ageing to this pattern using data from all population-based cancer registries (CRs) worldwide. Patients' median age at BC onset and that of the general population were extracted for CRs listed in volumes VI (1983-1987 years) through XI (2008-2012 years) of Cancer Incidence in Five Continents. Their association was assessed at cross-sectional level by linear regression model and longitudinally considering 25-year ageing of the population in long-standing CRs listed at the beginning and at the end of the study. During 2008-2012, each one-year increase of population ageing was associated with a nearly 1/2 year increase of age at BC diagnosis. Population demographics explained forty-two percent of the age variance for BC. In 1983-1987, long-standing CRs with a median age at BC below age 61.8 years showed an increase of age at BC after 25-years. Worldwide, age at BC diagnosis essentially reflected the median age of the population. Changes in BC detection methodology likely lessened this association. Nevertheless, the elevated absolute number of BCs in young populations deserves strategies of BC prevention.