Umpolung Amination: Nickel-Catalyzed Coupling Reactions of N,N-Dialkyl-N-chloroamines with Diorganozinc Reagents
Umpolung Amination: Nickel-Catalyzed Coupling Reactions of N,N-Dialkyl-N-chloroamines with Diorganozinc Reagents
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DOI：
10.1021/ja907038b
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发表时间：
2009-11-04
影响因子：
15
通讯作者：
Jarvo, Elizabeth R.
中科院分区：
文献类型：
--
作者：
Barker, Timothy J.;Jarvo, Elizabeth R.
N，N-二烷基-N-氯胺是镍催化偶联二芳基锌试剂的亲电氮的有效来源。在此条件下，各种N-氯胺和有机锌试剂均能顺利反应。一锅程序，避免了需要分离的N-氯胺的描述。
N,N-Dialkyl-N-chloroamines are an effective source of electrophilic nitrogen for nickel-catalyzed coupling with diarylzinc reagents. A variety of N-chloroamines as well as organozinc reagents react smoothly under the reaction conditions. A one-pot procedure that circumvents the need to isolate the N-chloroamines is described.