Enolase and arrestin are novel nonmyelin autoantigens in multiple sclerosis
Enolase and arrestin are novel nonmyelin autoantigens in multiple sclerosis
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DOI：
10.1007/s10875-007-9091-1
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发表时间：
2007-07-01
影响因子：
9.1
通讯作者：
Dosch, Hans-Michael
中科院分区：
文献类型：
--
作者：
Forooghian, Farzin;Cheung, Roy K.;Dosch, Hans-Michael
简介：虽然髓磷脂自身免疫是多发性硬化症（MS）发病机制中的一个主要因素，但非髓磷脂抗原的作用尚不清楚。考虑到这种疾病的复杂性，针对非髓鞘抗原的自身免疫也可能具有致病作用。先前已报告MS患者中存在针对烯醇化酶和抑制蛋白的自身抗体。然而，T细胞对这些抗原的反应尚未确定。方法：选取35例MS患者，沿着35例健康对照者。测定了针对非神经元烯醇化酶、神经元特异性烯醇化酶（NSE）、视网膜抑制蛋白、β-抑制蛋白和髓鞘碱性蛋白的T细胞增殖反应。结果如下：与健康对照组相比，MS患者对NSE、视网膜抑制蛋白和β-抑制蛋白的阳性T细胞增殖反应的发生率更高（p < 0.0001）。对NSE、视网膜抑制蛋白和β-抑制蛋白的增殖反应与对髓鞘碱性蛋白的反应相关（p
Introduction: Although myelin autoimmunity is known to be a major factor in the pathogenesis of multiple sclerosis (MS), the role of nonmyelin antigens is less clear. Given the complexity of this disease, it is possible that autoimmunity against nonmyelin antigens also has a pathogenic role. Autoantibodies against enolase and arrestin have previously been reported in MS patients. The T-cell response to these antigens, however, has not been established. Methods: Thirty-five patients with MS were recruited, along with thirty-five healthy controls. T-cell proliferative responses against non-neuronal enolase, neuron-specific enolase (NSE), retinal arrestin, beta-arrestin, and myelin basic protein were determined. Results: MS patients had a greater prevalence of positive T-cell proliferative responses to NSE, retinal arrestin, and beta-arrestin than healthy controls (p < 0.0001). The proliferative response against NSE, retinal arrestin, and beta-arrestin correlated with the response against myelin basic protein (p