Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling
Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling
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DOI：
10.1007/s13238-012-2058-x
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发表时间：
2012-10-01
期刊：
影响因子：
21.1
通讯作者：
Zhang, Long
中科院分区：
文献类型：
--
作者：
Gong, Kai;Zhou, Fangfang;Zhang, Long
We investigate the role of beta-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) using RAW264.7 cells. LPS rapidly stimulated cytosolic beta-catenin accumulation. beta-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activation-primed GSK3 beta inactivation by Akt was demonstrated to mediate the LPS induced beta-catenin accumulation. Overall, our findings suggest that suppression of GSK3 beta by ERK stimulates beta-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.
