Opiates inhibit neurogenesis in the adult rat hippocampus
Opiates inhibit neurogenesis in the adult rat hippocampus
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DOI：
10.1073/pnas.120552597
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发表时间：
2000-06-20
影响因子：
11.1
通讯作者：
Nestler, EJ
中科院分区：
文献类型：
--
作者：
Eisch, AJ;Barrot, M;Nestler, EJ
最近的研究表明，成年大鼠海马神经发生的调节是一种可塑性形式。鉴于已知的阿片类药物如吗啡和海洛因对海马功能的影响，我们研究了阿片类药物对该脑区神经发生的调节。慢性给药吗啡减少了42%的成年大鼠海马颗粒细胞层的神经发生。在长期自我施用海洛因后的大鼠中观察到类似的效果。阿片类调节神经发生的糖皮质激素循环水平的变化不介导，因为类似的效果，在接受肾上腺切除术和皮质酮替代大鼠。这些结果表明，阿片类药物调节成年大鼠海马神经发生可能是药物暴露影响海马功能的机制之一。
Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal function, we examined opiate regulation of neurogenesis in this brain region. Chronic administration of morphine decreased neurogenesis by 42% in the adult rat hippocampal granule cell layer. A similar effect was seen in rats after chronic self-administration of heroin. Opiate regulation of neurogenesis was not mediated by changes in circulating levels of glucocorticoids, because similar effects were seen in rats that received adrenalectomy and corticosterone replacement. These findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.