Mycobacterium tuberculosis Transmission in High-Incidence Settings-New Paradigms and Insights.
Mycobacterium tuberculosis Transmission in High-Incidence Settings-New Paradigms and Insights.
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DOI：
10.3390/pathogens11111228
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发表时间：
2022-10-25
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影响因子：
--
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结核病已经影响人类数千年，但直到 1882 年罗伯特·科赫 (Robert Koch) 发现结核分枝杆菌后，人们才对其病因和传播有了更深入的了解。此后人们获得了宝贵的见解，但对于这种仍然是地球上第一大传染病杀手的病原体来说，知识的积累却缓慢且不完整，令人沮丧。与此形成鲜明对比的是，我们在理解 SARS-CoV-2（COVID-19 的病因）空气生物学和传播方面取得了快速进展。在这篇综述中，我们讨论了有关结核分枝杆菌传播的重要历史和当代见解。描述了气溶胶传播原理以及相关病原体、宿主和环境因素的历史见解。此外，还讨论了对无症状和亚临床结核病的新见解，及其在人群传播中可能发挥的潜在作用。由于诊断工具欠佳、基础科学探索有限和研究设计不充分，在了解高负担环境中结核分枝杆菌传播的全谱方面取得的进展受到了阻碍。我们建议，作为结核病领域，我们必须学习并利用为研究 SARS-CoV-2 传播而开发的新见解和方法，以限制持续的结核病传播，从而维持全球大流行。
Tuberculosis has affected humankind for thousands of years, but a deeper understanding of its cause and transmission only arose after Robert Koch discovered Mycobacterium tuberculosis in 1882. Valuable insight has been gained since, but the accumulation of knowledge has been frustratingly slow and incomplete for a pathogen that remains the number one infectious disease killer on the planet. Contrast that to the rapid progress that has been made in our understanding SARS-CoV-2 (the cause of COVID-19) aerobiology and transmission. In this Review, we discuss important historical and contemporary insights into M. tuberculosis transmission. Historical insights describing the principles of aerosol transmission, as well as relevant pathogen, host and environment factors are described. Furthermore, novel insights into asymptomatic and subclinical tuberculosis, and the potential role this may play in population-level transmission is discussed. Progress towards understanding the full spectrum of M. tuberculosis transmission in high-burden settings has been hampered by sub-optimal diagnostic tools, limited basic science exploration and inadequate study designs. We propose that, as a tuberculosis field, we must learn from and capitalize on the novel insights and methods that have been developed to investigate SARS-CoV-2 transmission to limit ongoing tuberculosis transmission, which sustains the global pandemic.
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DOI：
10.1093/infdis/jix229
发表时间：
2017-09-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Datta S;Sherman JM;Tovar MA;Bravard MA;Valencia T;Montoya R;Quino W;D'Arcy N;Ramos ES;Gilman RH;Evans CA
通讯作者：
Evans CA
影响因子：
3.9
作者：
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通讯作者：
Coin, Lachlan
影响因子：
3.7
作者：
Bourouiba, Lydia;Dehandschoewercker, Eline;Bush, John W. M.
通讯作者：
Bush, John W. M.
DOI：
10.1164/rccm.201604-0769oc
发表时间：
2016-12-15
影响因子：
24.7
作者：
Chengalroyen, Melissa D.;Beukes, Germar M.;Kana, Bavesh D.
通讯作者：
Kana, Bavesh D.
影响因子：
158.5
作者：
Churchyard, Gavin J.;Fielding, Katherine L.;Grant, Alison D.
通讯作者：
Grant, Alison D.