Biological underpinnings of health alterations in women with PTSD: A sex disparity
Biological underpinnings of health alterations in women with PTSD: A sex disparity
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DOI：
10.1177/1099800405276709
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Page, GG
中科院分区：
文献类型：
--
作者：
Gill, JM;Szanton, SL;Page, GG
女性患创伤后应激障碍（PTSD）的比例是男性的两倍，尽管女性一生中经历创伤事件的人数少于男性。目前对PTSD患者的研究提供了神经内分泌系统改变的证据，这些改变涉及皮质醇和DHEA的水平和活性，以及免疫功能的变化，这些变化使这些个体倾向于先天性（Th1）免疫反应。然而，很少有研究涉及这些生物学改变在女性更容易患上PTSD中的可能作用。此外，目前的研究在将生物学改变与观察到的患有PTSD的女性的医疗状况比没有PTSD的女性增加四倍联系起来方面的能力有限。最后，很少有研究涉及PTSD患者合并重度抑郁症（MDD）的生物学影响。这篇重要的综述提供了与PTSD相关的神经内分泌和免疫紊乱的最新信息，并提出了与健康和PTSD发展中观察到的性别差异相关的可能机制的联系。
Women develop posttraumatic stress disorder (PTSD) at twice the rate of men, even though fewer women than men experience traumatic events over their lifetimes. Current studies of individuals with PTSD provide evidence of alterations in the neuroendocrine system that involve levels and activity of cortisol and DHEA and changes in immune function that predispose these individuals toward an innate (Th1) immune response. Yet few studies have addressed the possible role of these biologic alterations in women's increased vulnerability to developing PTSD. In addition, current studies are limited in their ability to link biologic alterations to the observed fourfold increase in medical conditions in women with PTSD as compared to women without PTSD. And finally, few studies have addressed the biologic impact of co-occurring major depressive disorder (MDD) in individuals with PTSD. This critical review provides an update on neuroendocrine and immune perturbations associated with PTSD with and without co-occurring MDD to suggest links to health and possible mechanisms underlying the observed sex disparity in the development of PTSD.