Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
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DOI：
10.1124/jpet.109.154955
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发表时间：
2010-01-01
影响因子：
3.5
通讯作者：
Marcoli, Manuela
中科院分区：
文献类型：
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作者：
Cervetto, Chiara;Maura, Guido;Marcoli, Manuela
我们发现，alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic酸(AMPA)和海人藻酸自身受体均存在于小脑平行/攀升纤维的谷氨酸释放终末，它们起易化性自身受体的作用。胞外cGMP抑制突触前海人酸受体激活引起的神经递质释放；胞外cGMP对海人酸自身受体介导的反应具有选择性，不影响AMPA自身受体介导的反应。内源性合成的cGMP可能是细胞外cGMP调节红藻氨酸自身受体激活反应的生理来源。
We found that both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate autoreceptors were present on the glutamate-releasing terminals of cerebellar parallel/climbing fibers and that they functioned as facilitatory autoreceptors. Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor-mediated response and did not affect the AMPA autoreceptor-mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation.