Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity
Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity
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含有简单线性酰基链或芳香环的甘油脂的合成及其 Mincle 信号活性的评估
DOI：
10.1039/c8cc07322h
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发表时间：
2019
影响因子：
4.9
通讯作者：
Maenaka Katsumi
中科院分区：
文献类型：
--
作者：
Matsumaru Takanori;Ikeno Risa;Shuchi Yusuke;Iwamatsu Toshiki;Tadokoro Takashi;Yamasaki Sho;Fujimoto Yukari;Furukawa Atsushi;Maenaka Katsumi
Mincle 在激活的吞噬细胞中表达，识别脂质配体以激活先天免疫系统。我们合成了具有简单烷基链或芳香环的甘油衍生物，并使用 Mincle 介导的信号分析阐明了它们的结构-活性关系。活性取决于甘油衍生物的简单酰基链的长度。
Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure–activity relationships using a Mincle-mediated signaling assay. The activity depends on the length of the simple acyl chains of the glycerol derivatives.