Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery.
Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery.
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DOI：
10.1007/s40495-015-0044-8
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发表时间：
2016-02
影响因子：
--
通讯作者：
Oupický D
中科院分区：
文献类型：
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作者：
Wang Y;Xie Y;Oupický D
本综述讨论了 CXCR4 趋化因子受体在抗癌和抗转移药物递送系统设计中的潜力。 CXCR4 在癌症进展和转移中的作用在几种类型的药物递送策略的开发的背景下进行了讨论。概述了靶向过度表达 CXCR4 的癌症的药物递送系统，以及靶向应用中使用的 CXCR4 结合配体的主要类型。还讨论了利用 CXCR4 抑制来增强联合治疗的抗癌和抗转移活性的药物递送应用。
This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.