Nonlinear phase dispersion spectroscopy.
Nonlinear phase dispersion spectroscopy.
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DOI：
10.1364/ol.36.004665
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发表时间：
2011-12-01
期刊：
影响因子：
3.6
通讯作者：
Wax A
中科院分区：
文献类型：
--
作者：
Robles FE;Satterwhite LL;Wax A
介绍了非线性相位色散光谱（NLDS）作为一种获取波长相关的折射率实部的宽带、高光谱分辨率剖面的方法。该方法是基于检测通过薄样品传输的低相干光场的色散效应，并在光谱域进行干涉检测。同样的采样信号也被处理，分别使用光谱域相位显微镜（SDPM）和光谱光学相干层析成像（SOCT）得到关于总衰减系数的定量相位图和光谱信息。使用荧光和非荧光聚苯乙烯珠的概念验证实验，以及另一个使用红细胞的概念验证实验证明了该方法量化各种吸收/分散特征的能力。与基于强度的光谱（例如SOCT）相比，这种新方法的灵敏度增加，并讨论了潜在的应用。
Non-linear phase dispersion spectroscopy (NLDS) is introduced as a means to retrieve wide-band, high spectral resolution profiles of the wavelength-dependent, real part of the refractive index. The method is based on detecting dispersion effects imparted to a light field with low coherence transmitted through a thin sample and detected interferometrically in the spectral domain. The same sampled signal is also processed to yield quantitative phase maps and spectral information regarding the total attenuation coefficient using spectral domain phase microscopy (SDPM) and spectroscopic optical coherence tomography (SOCT), respectively. Proof of concept experiments using fluorescent and non-fluorescent polystyrene beads, and another using a red blood cell demonstrate the ability of the method to quantify various absorptive/dispersive features. The increased sensitivity of this novel method is compared to intensity-based spectroscopy (e.g., SOCT) and potential applications are discussed.