Recent advances in host defense mechanisms/therapies against oral infectious diseases and consequences for systemic disease.
Recent advances in host defense mechanisms/therapies against oral infectious diseases and consequences for systemic disease.
复制标题
DOI：
10.1177/0022034514525778
复制
发表时间：
2014-05-01
影响因子：
--
通讯作者：
Van Dyke, T E
中科院分区：
文献类型：
--
作者：
Gaffen, S L;Herzberg, M C;Van Dyke, T E
先天性和适应性免疫系统对口腔疾病机制及其对全身健康状况的影响都至关重要。更好地理解这些相互关系将产生机会，以确定新的治疗靶点，以调节疾病的过程和/或增加宿主对感染或炎症的抵抗力。所讨论的主题反映了我们对先天性和适应性免疫系统以及炎症机制在影响口腔的感染性疾病（包括牙周炎和念珠菌病）中的作用的认识的最新进展。此外，还探讨了与全身炎症性疾病（如心血管疾病）的几种潜在联系。这些发现阐明了宿主组织利用的一些防御机制，包括IL-17在提供对口腔念珠菌病的免疫力中的作用，粘膜上皮细胞的抗菌防御，以及天然炎症调节剂proresolvins和lipoxins的促消退作用。他们还描述了免疫细胞在牙周病中介导病理性骨吸收的作用。这些见解突出了免疫调节干预的治疗益处的潜力，其支持或调节口腔和全身性疾病中的宿主防御机制。在这里讨论的有前途的新的治疗方法是上皮细胞基因治疗，被动免疫对免疫细胞的目标，并使用proresolvin剂。
The innate and adaptive immune systems are both crucial to oral disease mechanisms and their impact on systemic health status. Greater understanding of these interrelationships will yield opportunities to identify new therapeutic targets to modulate disease processes and/or increase host resistance to infectious or inflammatory insult. The topics addressed reflect the latest advances in our knowledge of the role of innate and adaptive immune systems and inflammatory mechanisms in infectious diseases affecting the oral cavity, including periodontitis and candidiasis. In addition, several potential links with systemic inflammatory conditions, such as cardiovascular disease, are explored. The findings elucidate some of the defense mechanisms utilized by host tissues, including the role of IL-17 in providing immunity to oral candidiasis, the antimicrobial defense of mucosal epithelial cells, and the pro-resolution effects of the natural inflammatory regulators, proresolvins and lipoxins. They also describe the role of immune cells in mediating pathologic bone resorption in periodontal disease. These insights highlight the potential for therapeutic benefit of immunomodulatory interventions that bolster or modulate host defense mechanisms in both oral and systemic disease. Among the promising new therapeutic approaches discussed here are epithelial cell gene therapy, passive immunization against immune cell targets, and the use of proresolvin agents.